EFFECT OF SELENIUM DEFICIENCY ON THE CHRONIC TOXICITY OF ADRIAMYCIN IN RATS

缺硒对阿霉素大鼠慢性毒性的影响

• 批准号: 3942920
• 负责人: V J FERRANS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3942920
• 关键词: cardiotoxin; doxorubicin; drug adverse effect; malnutrition; nutrition related tag; renal toxin; selenium; tocopherols

A study was made of the effect of selenium deficiency on the chronic toxicity produced by doxorubicin in rats fed diets adequate in vitamin E. The severity of the cardiotoxicity was unaltered by selenium deficiency; however, the growth-inhibiting effect and the nephrotoxicity produced by doxorubicin were more marked in the selenium-deficient animals.

研究了缺硒对人体的影响 阿霉素对大鼠饮食产生的慢性毒性 维生素E含量充足。心脏毒性的严重程度是 不因缺硒而改变；然而，生长抑制 阿霉素的作用和肾毒性更大 在缺硒动物中明显可见。

项目成果

Oxidant stress mediates inflammation and apoptosis in ventilator-induced lung injury.

氧化应激介导呼吸机引起的肺损伤中的炎症和细胞凋亡。

• DOI: 10.1111/j.1440-1843.2008.01279.x
• 发表时间: 2008
• 期刊: Respirology (Carlton, Vic.)
• 作者: Syrkina,Olga;Jafari,Behrouz;Hales,CharlesA;Quinn,DeborahA
• 通讯作者: Quinn,DeborahA