BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY

该项目旨在开发新的仪器和方法或 改进现有的仪器和方法，以表征 生物大分子及其相互作用的研究。分析性 超速离心法、辅助技术和数据处理方法 使用适合于这些技术的数学建模的分析是 感兴趣的主要领域。 这个项目的主要重点是开发新的 数学建模技术在数学建模中的应用 超速离心分析。这个项目一直关注的两个领域 With是隐式约束方法的扩展， 更广泛的大分子相互作用研究和新途径 关于获得溶液中分子量分布的研究 大分子生物聚合物。在DEC-10计算机上运行的MLab 被用于数学建模。这些研究的应用 在题为物理化学的年度报告中进行了描述 生物大分子。 没有开展任何关于数据采集的新工作，除了 继续研究开发新光学器件的可能性 用于当前制备剂转换的数据采集系统 超速离心法转变为分析型超速离心法 作为分析工具的能力，成本只有 目前的仪器。这类系统的新的初步设计已经完成 发展起来的。

The project is designed to develop new instrumentation and methodology or improve existing instrumentation and methodology for characterization of biological macromolecules and for studying their interactions. Analytical ultracentrifugation, the techniques ancillary to it, and methods of data analysis using mathematical modeling appropriate for these techniques are the major areas of interest. The major emphasis in this project has been given to the development of new applications of the techniques of mathematical modeling to problems in ultracentrifugal analysis. The two areas this project has been concerned with have been an extension of the method of implicit constraints to a wider range of studies of macromolecular interactions and a new approach toward obtaining molecular weight distributions in solutions of macromolecular biopolymers. MLAB, operating on the DEC-10 computer, has been used for the mathematical modeling. The applications of these studies are described in the annual report entitled Physical Chemistry of Biological Macromolecules. No new work on data acquisition has been carried out except for the continuation of a study on the possibility of development of new optical data acquisition systems for the conversion of curent preparative ultracentrifuges into analytical ultracentrifuges with superior capabilities as analytical instruments at a fraction of the cost of the current instruments. New preliminary designs for such systems have been developed.