BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY

生物物理仪器和方法

• 批准号: 5204045
• 负责人: M S LEWIS
• 金额: --
• 依托单位: NATIONAL CENTER FOR RESEARCH RESOURCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5204045
• 关键词: analytical ultracentrifugation; biomedical equipment development; biophysics; image processing; intermolecular interaction; macromolecule; mathematical model; method development; model design /development; nucleic acid metabolism; protein metabolism

The project is intended to develop new instrumentation and methods, and to improve existing instrumentation and techniques, for the characterization of biological macromolecules and the study of their interactions. Analytical ultracentrifugation, the techniques ancillary to it, and methods of data analysis using mathematical modeling appropriate for these techniques are the major areas of interest. Studies have continued on the application of mathematical modeling to problems of ultracentrifugal analysis, and on the development of new methods of performing experiments and analyzing data. The 1994 report described the development of a new method of performing experiments and analyzing data for the analysis of protein-nucleic acid and protein-protein interactions. Work in this area has continued, with emphasis on developing faster and easier methods of using MLAB. Other studies have been initiated on the application of signal processing and image enhancement techniques to ultracentrifugal data analysis.

该项目旨在开发新的仪器和方法， 并改进现有的工具和技术，以实现 生物大分子的表征及其研究进展 互动。分析超速离心法，技术 它的辅助工具，以及使用数理统计进行数据分析的方法 适合这些技术的建模是的主要领域 利息。 关于数学建模的应用研究仍在继续 超速离心分析中存在的问题及新技术的发展 进行实验和分析数据的方法。1994年的报告 描述了一种进行实验的新方法的发展 和分析蛋白质-核酸分析的数据和 蛋白质之间的相互作用。这一领域的工作仍在继续， 重点是开发更快、更容易使用MLAB的方法。其他 已经开始了对信号处理应用的研究 以及图像增强技术，用于超速离心数据分析。