BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY

生物物理仪器和方法

• 批准号: 3937284
• 负责人: M S LEWIS
• 金额: --
• 依托单位: DIVISION OF RESEARCH SERVICES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3937284
• 关键词: analytical ultracentrifugation; computer simulation; fluorescence; macromolecule; mathematical model; model design /development

The project is designed to develop new instrumentation and methods and to improve existing instrumentation and techniques for the characterization of biological macromolecules and for study of their interactions. Analytical ultracentrifugation, the techniques ancillary to it, and methods of data analysis using mathematical modeling appropriate for these techniques are the major areas of interest. Studies on the application of mathematical modeling to problems of ultracentrifugal analysis have been continued. The applications of these studies are described in the project report 10184-05. Major progress has been made in the development of data acquisition systems. A data acquisition system using the IBM XT computer has been completed and successfully tested and a similar, but more sophisticated and flexible system using the Macintosh II is nearing completion. New methods of performing experiments and analyzing data have been developed and work is continuing in this area. Feasibility studies toward the development of fluorescence scanning data acquisition systems of very high sensitivity have been continued.

该项目旨在开发新的仪器和方法 并改进现有的仪器和技术， 生物大分子的表征和研究 他们的互动。 分析超浓缩技术， 辅助它，以及使用数学的数据分析方法 适用于这些技术的建模是 兴趣 数学建模在工程问题中的应用研究 超临界分析仍在继续。 应用 项目报告10184-05中描述了这些研究。 数据采集的发展取得了重大进展 系统. 采用IBM XT计算机的数据采集系统， 已经完成并成功测试，类似的，但更多 使用Macintosh II的复杂而灵活的系统即将推出 建成 进行实验和分析的新方法 已经编制了数据，这方面的工作正在继续。 发展荧光扫描的可行性研究 非常高灵敏度的数据采集系统已经 持续期间内的