BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY

生物物理仪器和方法

• 批准号: 3789382
• 负责人: M S LEWIS
• 金额: --
• 依托单位: NATIONAL CENTER FOR RESEARCH RESOURCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3789382
• 关键词: analytical method; analytical ultracentrifugation; biomedical equipment development; biophysics; intermolecular interaction; macromolecule; mathematical model; method development; model design /development

The project is intended to develop new instrumentation and methods, and to improve existing instrumentation and techniques, for the characterization of biological macromolecules and the study of their interactions. Analytical ultracentrifugation, the techniques ancillary to it, and methods of data analysis using mathematical modeling appropriate for these techniques are the major areas of interest. Studies have continued on the application of mathematical modeling to problems of ultracentrifugal analysis, and on the development of new methods of performing experiments and analyzing data. In particular, a major breathrough in the analysis of protein-nucleic acid and protein-protein interactions has been achieved by devising a new method of performing experiments and analyzing data.

该项目旨在开发新的仪器和方法，以及 改进现有仪器和技术， 生物大分子的表征及其研究 互动。 分析超速离心，辅助技术 以及使用数学建模的数据分析方法 适合这些技术的是主要感兴趣的领域。 数学模型应用的研究仍在继续 超速离心分析存在的问题以及新方法的开发 进行实验和分析数据的方法。 尤其， 蛋白质核酸分析的一次重大突破 通过设计一种新方法实现了蛋白质-蛋白质相互作用 进行实验和分析数据。