PRODUCTION OF COVALENTLY CROSS-LINKED IMMUNE COMPLEXES

共价交联免疫复合物的产生

• 批准号: 4689944
• 负责人: P H PLOTZ
• 金额: --
• 依托单位: NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4689944
• 关键词: Kupffer's cell; antibody formation; antibody specificity; biological models; complement fixation tests; crosslink; haptens; immune complex; immunoglobulins; immunopathology; immunopharmacology; intravenous administration; liver cells; systemic lupus erythematosus

Studies underway continue earlier observations on immune complex biology using site-specifically cross-linked model complexes. Two major aspects are under study at the moment. First, the hepatic handling of model complexes in auto-immune mice is being studied in detail using organ perfusion. This approach allows a more detailed and subtle understanding than whole animal studies. Auto-immune mice show an abnormality in handling complexes before they are clinically ill. Second, in studies underway, the influence of drugs which are known to ameliorate auto-immune disease upon immune complex handling in normal and auto-immune mice, is being explored.

正在进行的研究继续早期对免疫复合物生物学的观察 使用位点特异性交联的模型复合物。 两个大的方面 目前正在研究中。 一、模型的肝脏处理 复合物在自身免疫小鼠正在详细研究使用器官 灌注。 这种方法允许更详细和微妙的理解 比整个动物实验更好 自身免疫小鼠显示异常， 在他们临床上生病之前处理复杂的情况。 第二，在研究中 正在进行中，已知可以改善自身免疫的药物的影响 在正常和自身免疫小鼠中， 正在探索中。