PHYSIOLOGICAL ANALYSIS OF INVOLUNTARY MOVEMENTS

肌阵挛和其他一些快速不自主运动已经被 临床上很难分类。 合并患者材料 通过对NIH新病例的持续分析， 导致了新的分类和病理生理学的见解。 结论 关于癫痫性质的肌阵挛，成人发作的抽搐， 吓一跳。 震颤也很难分类。 在研究生理过程中 这些疾病的方面，我们已经确定了一个新的描述， 小脑姿势性震颤，这可能有助于区分它从其他 姿势性震颤 小脑姿势性震颤的幅度 似乎取决于四肢的精确姿势，特别是， 当手臂靠近身体并且手指向时， 彼此相对 这在生理上的影响 探讨了 我们还研究了几个直立性震颤的患者， 奇怪的，新描述的腿部震颤的障碍，只有当 站着 我们的初步研究表明这是一种 平衡机制 我们计划继续这些研究，并增加PET扫描作为一种生理检查。 我们的一系列临床神经生理学方法的工具，以帮助识别 不自主运动患者大脑中的异常区域。

Myoclonus and a number of other rapid involuntary movements have been difficult to classify clinically. Consolidation of patient material obtained outside of NIH with continuing analysis of new cases at NIH has led to new classifications and pathophysiological insights. Conclusions have been drawn about myoclonus of epileptic nature, adult onset tic and startle. Tremors are also difficult to classify. In studying the physiological aspects of these disorders, we have identified a new descriptor of cerebellar postural tremor which may help distinguish it from other postural action tremors. The amplitude of cerebellar postural tremor appears to depend on the precise posture of the limbs, and, in particular, is highest when the arms are near the body and the hands are pointing toward each other. The physiological implications of this are being explored. We have also studied several patients with orthostatic tremor, a curious, newly described disorder of tremor of the legs only when standing. Our preliminary studies suggest that this is a disorder of the balance mechanism. We plan to continue these studies and add PET scanning as a physiological tool to our battery of clinical neurophysiological methods to help identify abnormal areas in the brains of patients with involuntary movements.