PHYSIOLOGICAL ANALYSIS OF INVOLUNTARY MOVEMENTS

不自主运动的生理分析

• 批准号: 3860820
• 负责人: M HALLETT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3860820
• 关键词: abnormal involuntary movement; cerebral degeneration; clinical trials; diagnosis design /evaluation; electrical potential; facial muscles; human subject; human therapy evaluation; joint stiffness; muscle pharmacology; myoclonus; neuromuscular disorder diagnosis; neuropharmacology; neurophysiology; olivocochlear bundle; pathology; reflex disorder; startle reaction; synapses; tremor

Involuntary movements have often been difficult to classify clinically. Clinical and physiological analysis of a continuing series of patients has led to new classifications and pathophysiological insights. Patients with myoclonus have been studied to seek further understanding of this confusing involuntary movement. Extensive studies have classified most cases seen within previously identified categories. We are trying to define criteria that would delineate hysterical myoclonus unambiguously. We have studied some patients with periodic movements in sleep and dyskinesias while awake in patients with the restless legs syndrome. We have seen that some of these involuntary movements share a similar appearance to normal flexor reflexes. Detailed clinical and physiologic studies have been done in patients with palatal tremor (myoclonus). We have further data confirming the division of these patients into two groups: idiopathic and secondary. We have studied three patients with stiff-man syndrome seeking to understand the pathophysiology. We have found abnormalities in presynaptic inhibition in all. Other abnormalities are not consistent. Other investigations include a study of movement related cortical potentials in patients with tic and a physiologic investigation of facial twitching seen in patients with olivopontocerebellar atrophy. A therapeutic trial with trazadone is in progress for patients with essential tremor that has not responded to standard therapy. Preliminary results show that some patients will benefit from this drug. We have studied several patients in a family with hyperekplexia. Our results showed that movement in these patients is an exaggerated startle reflex.

不自主运动在临床上通常很难分类。 连续系列患者的临床和生理分析 导致了新的分类和病理生理学的见解。 对肌阵挛患者进行了研究，以寻求进一步的了解 这种令人困惑的无意识运动。 了大量的研究 将大多数病例归入先前确定的类别。 我们 正试图定义癔症性肌阵挛的标准 毫不含糊 我们研究了一些周期性运动的患者， 不宁腿患者清醒时的睡眠和运动障碍 综合征 我们已经看到，这些无意识运动中的一些共享一个 与正常屈肌反射相似。 详细的临床和生理学研究已经在患者中完成， 腭震颤（肌阵挛）。 我们有进一步的数据证实 这些患者分为两组：特发性和继发性。 我们研究了三名僵硬人综合征患者， 了解病理生理学。我们发现了一些异常 突触前抑制。 其他异常不一致。 其他研究包括运动相关的皮质 抽动患者的潜力和面部生理调查 橄榄体脑桥小脑萎缩患者出现抽搐。 曲唑酮的治疗试验正在进行中， 对标准治疗没有反应的特发性震颤。 初步 结果表明，一些患者将受益于这种药物。 我们研究了一个家族的几个病人与hyperkplexia。 我们 结果显示，这些患者的运动是一种夸张的惊吓， 反射。