UTILITY AND PHYSIOLOGY OF BOTULINUM TOXIN FOR INVOLUNTARY MOVEMENT DISORDERS

肉毒杆菌毒素治疗不自主运动障碍的效用和生理学

• 批准号: 6111853
• 负责人: M HALLETT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6111853
• 关键词: abnormal involuntary movement; acetylcholine; botulinum toxins; clinical research; clinical trials; human subject; human therapy evaluation; longitudinal human study; muscle cramp; neuromuscular disorder chemotherapy; neuromuscular junction; physiology; torticollis; tremor

We have been studying the efficacy of local injections of botulinum toxin for the treatment of different types of focal dystonias. Botulinum toxin injected in small doses directly into muscle, binds to and inactivates the neuromuscular junction. Dystonic contraction is decreased and function improves Treatment is well-tolerated with minimal side effects. We have also been using botulinum toxin to study the physiology of focal dystonias. We have continued the treatment of patients with writer's cramp. These patients are active participants in physiology protocols including transcranial magnetic stimulation, PET, microneurography and somatosensory evoked potentials studies. We have demonstrated that immediate exercise following injection in writer's cramp patients leads to greater loss of strength. We continued to study the long-term effects of botulinum toxin type F for patients who lose response to type A due to antibodies and for patients who never responded to type A despite adequate doses. Two patients who previously responded became resistant to the effects of botulinum toxin F. These responses are being investigated with testing for botulinum toxin F antibodies.

我们一直在研究当地 注射肉毒杆菌毒素治疗不同类型的 局部肌张力障碍将小剂量肉毒杆菌毒素直接注射到 肌肉，与神经肌肉接头结合并使其失活。 肌张力障碍性收缩减少，功能改善治疗 耐受性好副作用小我们也一直在使用 肉毒杆菌毒素来研究局部肌张力障碍的生理学。我们 继续治疗书写痉挛患者这些 患者积极参与生理学方案，包括 经颅磁刺激、PET、显微神经造影术和 体感诱发电位研究。我们已经证明 在书写痉挛注射后立即进行的练习 患者会失去更多的力量。我们继续研究 F型肉毒杆菌毒素对失去治疗的患者的长期影响 由于抗体对A型的反应，对于从未 对A型血有反应的两名患者 先前有反应的人对肉毒杆菌的作用产生了抵抗力， F毒素正在对这些反应进行调查， 肉毒杆菌毒素F抗体。