GLUCOSE THRESHOLD FOR CEREBRAL DYSFUNCTION DURING HYPOGLYCEMIA IN IDDDM

IDDDM 低血糖期间脑功能障碍的血糖阈值

• 批准号: 5219676
• 负责人: ROBERT S SHERWIN
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5219676
• 关键词: blood glucose; cerebrum; clinical research; cognition disorders; glucose clamp technique; human subject; hypoglycemia; insulin dependent diabetes mellitus; medical complication; psychomotor reaction time; stimulus /response

Clinical observation suggests that cognitive function can remain impaired after hypoglycemia, despite normalization of plasma glucose. To determine that such a delay occurs, and whether it is influenced by the duration of hypoglycemia, we compared P300 latency (prolongation is a marker of hypoglycemic cognitive dysfunction), after different periods of hypoglycemia. 17 normal volunteers had 2 hypoglycemic clamp studies. Plasma glucose was lowered to 50mg/dl for 60 or 180 min. P300 latency was measured at baseline, during hypoglycemia and during glucose recovery. All subjects showed P300 prolongation during hypoglycemia. No change was seen during 3 euglycemic control studies. We plan to measure the delay in normalization of cognitive function after hypoglycemia in poorly controlled diabetics, we expect this will be more prolonged.

临床观察表明，认知功能可以保持受损 低血糖后，尽管血糖正常化。 到 确定这种延迟发生，以及它是否受到 低血糖持续时间，我们比较了P300潜伏期（延长是低血糖持续时间的一个因素）。 低血糖认知功能障碍的标志物），在不同时期后 低血糖症 17名正常志愿者进行了2次低血糖钳夹试验。 血糖降至50 mg/dl持续60或180分钟。 在基线、低血糖期间和血糖期间测量 复苏 所有受试者在低血糖期间均显示P300延长。没有 在3项血糖正常对照研究中观察到变化。 我们计划测量 低血糖后认知功能正常化延迟， 对于控制不佳的糖尿病患者，我们预计这种情况会持续更长时间。