SPATIOTEMPORAL ANALYSIS OF MAGNETOCARDIOGRAM

这项拨款申请建议扩大生物磁力的用途。 测量进入一个相对较新的研究领域--胎儿的研究 心脏活动。目前，超声波是临床上唯一使用的方法。 以评估人类胎儿的心脏活动。开发一种完全的 提供补充信息的安全、非侵入性技术可能 具有重要的意义。潜在的临床应用包括检测 胎儿心脏异常和胎儿窘迫与缺氧或 酸血症。 从理论上讲，有充分的理由证明使用磁力 用于胎儿评估的检测。这里清楚地展示了试点研究 记录这些优势。拟议研究的主要目的 是为了检验快速消费品可以用于临床测量的假设 大范围胎儿心功能的重要参数 孕龄。心脏功能异常的胎儿将被包括在 这项研究。研究数据还将提供详细的新信息 关于胎心率变异性和胎心率的时空特性 快消品。拟实现的具体目标如下： 1)测定正常胎儿和新生儿的FMCG波形参数 心功能异常，包括PR间期、QRS间期、PR-RR 相关性，和胎心向量。 2)胎儿心率发育的特征和研究 在广泛的孕龄范围内的可变性， 3)开发准确测量位置和方向的方法 宫内胎儿，以便研究它们对快速消费品的影响 可以显示关于胎儿的FMCG映射数据。

This grant application proposes to extend the use of biomagnetic measurement into a relatively new research area- - the study of fetal heart activity. Presently, ultrasound is the only method used clinically to assess heart activity of the human fetus. Development of a completely safe, noninvasive technique that provides complementary information could have great significance. Potential clinical applications include detection of fetal heart anomalies and fetal distress associated with hypoxia or acidemia. There is strong theoretical justification for the use of magnetic detection for fetal assessment. Pilot studies presented here clearly document these advantages. The primary purpose of the proposed research is to test the hypothesis that FMCG can be employed to measure clinically important parameters of fetal cardiac function over a wide range of gestation ages. Fetuses with abnormal heart function will be included in the study. The study data will also yield detailed new information regarding fetal heart rate variability and spatiotemporal properties of the FMCG. The specific aims to be achieved are as follows: 1) To measure FMCG waveform parameters in fetuses and neonates with normal and abnormal heart function, including PR interval, QRS duration, PR-RR correlation, and fetal heart vector. 2) To characterize and study the development of fetal heart rate variability over a wide range of gestational age, 3) To develop methods to accurately measure position and orientation of the fetus in utero so that their influence on the FMCG can be studied and FMCG mapping data can be displayed with respect to the fetus.