Policy analysis of the drivers of antimicrobial resistance within Tanzania's one-health care systems

坦桑尼亚单一医疗保健系统内抗生素耐药性驱动因素的政策分析

• 批准号: MR/S012796/1
• 负责人: Mecky Matee
• 金额: $ 25.79万
• 依托单位: Muhimbili University of Health and Allied Sciences
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FS012796%2F1
• 关键词: Policy; analysis; drivers; antimicrobial; resistance

The causes and impacts of AMR are multi-factorial, not confined to biological, environmental, clinical, or social-economic domains, therefore inter-disciplinary approaches are needed. The proposed project aims to uncover the covert and overt drivers of AMR within Tanzania's health system and the pig production sector using a multi-method and interdisciplinary, "One Health" research approach. First, we will conduct a needs assessment based on a literature and policy document review as well participant observations at key sites in the human and animal health systems. Second, we will conduct a stakeholder analysis which will involve comprehensively mapping out the range of actors involved in policy processes relating to appropriate use of antimicrobials, across the One Health spectrum including formal and informal sector actors. Third, once politically feasible interventions addressing key issues indicated by the needs assessment have been identified we will pilot test an intervention targeted at critical segments within healthcare and/or veterinary systems. Fourth, we will present finding to policymakers and investigate how the new information influences their support or opposition for policy implementation. The overall expected outcome will be a cost effective, evidence base for policy recommendations, which are relevant in human and animal health systems in Tanzania. By engaging with key policy actors in Tanzania - including the National AMR Coordinating Committee, the technical working groups, the secretariat and the AMR focal point - we will contribute evidence to inform strategies for implementation of the National AMR Action Plan and serve as a model for other resource limited countries. Policy briefs with synthesised evidence on the role of health and veterinary systems in the contribution and persistence of AMR will be a key output. We anticipate that the information generated from this research will be used in strengthening systems for antimicrobial distribution and use.

AMR的原因和影响是多因素的，不限于生物、环境、临床或社会经济领域，因此需要跨学科的方法。拟议的项目旨在利用多方法和跨学科的“同一健康”研究方法，揭示坦桑尼亚卫生系统和生猪生产部门中AMR的隐蔽和公开驱动因素。首先，我们将根据文献和政策文件审查以及参与者在人类和动物卫生系统关键地点的观察结果进行需求评估。第二，我们将进行利益攸关方分析，这将涉及全面规划参与与适当使用抗菌剂有关的政策进程的各种行为者，包括正式和非正式部门的行为者。第三，一旦确定了解决需求评估所指出的关键问题的政治上可行的干预措施，我们将对针对医疗保健和/或兽医系统关键部分的干预措施进行试点测试。第四，我们将向政策制定者展示调查结果，并调查新信息如何影响他们对政策实施的支持或反对。总体预期成果将为政策建议提供具有成本效益的证据基础，这些建议与坦桑尼亚的人类和动物卫生系统有关。通过与坦桑尼亚的主要政策行为者--包括全国抗灾减灾协调委员会、技术工作组、秘书处和抗灾减灾联络点--进行接触，我们将提供证据，为执行《国家抗灾减灾行动计划》的战略提供依据，并为其他资源有限的国家树立榜样。载有关于卫生和兽医系统在AMR的贡献和持久性中的作用的综合证据的政策简报将是一项关键产出。我们预计，这项研究产生的信息将用于加强抗菌剂分配和使用的系统。

项目成果

Knowledge, attitudes and practices regarding antimicrobial use and resistance among communities of Ilala, Kilosa and Kibaha districts of Tanzania.

• DOI: 10.1186/s13756-020-00862-y
• 发表时间: 2020-12-07
• 期刊: Antimicrobial resistance and infection control
• 影响因子: 5.5
• 作者: Sindato C;Mboera LEG;Katale BZ;Frumence G;Kimera S;Clark TG;Legido-Quigley H;Mshana SE;Rweyemamu MM;Matee M
• 通讯作者: Matee M

The Governance and Implementation of the National Action Plan on Antimicrobial Resistance in Tanzania: A Qualitative Study.

• DOI: 10.3390/antibiotics10030273
• 发表时间: 2021-03-09
• 期刊: Antibiotics (Basel, Switzerland)
• 作者: Frumence G;Mboera LEG;Sindato C;Katale BZ;Kimera S;Metta E;Durrance-Bagale A;Jung AS;Mshana SE;Clark TG;Rweyemamu M;Legido-Quigley H;Matee MIN
• 通讯作者: Matee MIN

BMC

BMC

• 发表时间: 2022
• 作者: Azabo

Practices and Challenges of Veterinary Paraprofessionals in Regards to Antimicrobial Use and Resistance in Animals in Dar Es Salaam, Tanzania.

• DOI: 10.3390/antibiotics10060733
• 发表时间: 2021-06-17
• 期刊: Antibiotics (Basel, Switzerland)
• 作者: Frumence G;Mboera LEG;Sindato C;Durrance-Bagale A;Jung AS;Mshana SE;Clark TG;Legido-Quigley H;Matee MI
• 通讯作者: Matee MI

Framing the Drivers of Antimicrobial Resistance in Tanzania.

• DOI: 10.3390/antibiotics10080991
• 发表时间: 2021-08-16
• 期刊: Antibiotics (Basel, Switzerland)
• 作者: Durrance-Bagale A;Jung AS;Frumence G;Mboera L;Mshana SE;Sindato C;Clark TG;Matee M;Legido-Quigley H
• 通讯作者: Legido-Quigley H