BIOPHYSICAL STUDIES ON PROTEIN FOLDING BY MASS SPECTROMETRY
BIOPHYSICAL STUDIES ON PROTEIN FOLDING BY MASS SPECTROMETRY
批准号:
6120206
负责人:
MICHAEL A BALDWIN
金额:
$2.21万
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-03-01 至 2000-02-29
中文摘要
近年来,质谱法已开始被用作一种检测方法
英文摘要
In recent years mass spectrometry has started to be used as a
method to monitor the dynamics of protein folding. We will explore
this aspect of MS using at least two different approaches: (i) The
detection of protected protein domains by limited proteolytic
isolation of protected species from SDS-PAGE gels and identification
using further digestion and MALDI or ESI-MS. (ii) monitoring the
kinetics of H/D exchange at physiological pH (fast exchange) followed
by pepsin digestion at low pH (slow exchange) and identification of
protected regions as a function of time. We will investigate the
application of these techniques to biological problems, such as
identification of different folds caused by mutations in the
steroidogenic acute regulatory protein StAR.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
CORE--SCIENCE FACILITY
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批准号:7447342
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项目类别:
-
资助金额:$28.12万
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财政年份:2007
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负责人:MICHAEL A BALDWIN
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依托单位:
BIOPHYSICAL STUDIES ON PROTEIN FOLDING BY MASS SPEC:THE STEROIDOGENIC ACUTE REG
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批准号:7369035
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项目类别:
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资助金额:$2.04万
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财政年份:2006
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负责人:MICHAEL A BALDWIN
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依托单位:
TOWARD UNDERSTANDING MECHANISM OF MALDI PROCESS
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批准号:7369033
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项目类别:
-
资助金额:$0.11万
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财政年份:2006
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负责人:MICHAEL A BALDWIN
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依托单位:
BIOPHYSICAL STUDIES ON PROTEIN FOLDING BY MASS SPEC:THE STEROIDOGENIC ACUTE REG
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批准号:7180917
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项目类别:
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资助金额:$5.44万
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财政年份:2005
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负责人:MICHAEL A BALDWIN
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依托单位:
TOWARD UNDERSTANDING MECHANISM OF MALDI PROCESS
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批准号:7180915
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项目类别:
-
资助金额:$1.0万
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财政年份:2005
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负责人:MICHAEL A BALDWIN
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依托单位:
Core--Science
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批准号:6742799
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项目类别:
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资助金额:$21.0万
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财政年份:2004
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负责人:MICHAEL A BALDWIN
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依托单位:
TOWARD UNDERSTANDING MECHANISM OF MALDI PROCESS
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批准号:6976602
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项目类别:
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资助金额:$23.11万
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财政年份:2004
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负责人:MICHAEL A BALDWIN
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依托单位:
BIOPHYSICAL STUDIES ON PROTEIN FOLDING BY MASS SPEC
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批准号:6976604
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项目类别:
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资助金额:$3.3万
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财政年份:2004
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负责人:MICHAEL A BALDWIN
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依托单位:
EXPLOSIVE MATRIX ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY
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批准号:6120204
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项目类别:
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资助金额:$6.2万
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财政年份:1999
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负责人:MICHAEL A BALDWIN
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依托单位:
CORE--SCIENTIFIC
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批准号:6112237
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项目类别:
-
资助金额:$18.35万
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财政年份:1999
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负责人:MICHAEL A BALDWIN
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依托单位:
SYNTHETIC AND RECOMBINANT PRP PEPTIDES AND PROTEINS
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批准号:6098430
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项目类别:
-
资助金额:$23.85万
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财政年份:1999
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负责人:MICHAEL A BALDWIN
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依托单位:
CORE-SCIENTIFIC
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批准号:6098432
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项目类别:
-
资助金额:$23.85万
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财政年份:1999
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负责人:MICHAEL A BALDWIN
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依托单位:
SYNTHETIC AND RECOMBINANT PRP PEPTIDES AND PROTEINS
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批准号:6267583
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项目类别:
-
资助金额:$22.55万
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财政年份:1998
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负责人:MICHAEL A BALDWIN
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依托单位:
CORE--SCIENTIFIC
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批准号:6267182
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项目类别:
-
资助金额:$22.24万
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财政年份:1998
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负责人:MICHAEL A BALDWIN
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依托单位:
CORE--SCIENTIFIC
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批准号:6273724
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项目类别:
-
资助金额:$17.65万
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财政年份:1998
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负责人:MICHAEL A BALDWIN
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依托单位:
CORE-SCIENTIFIC
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批准号:6267585
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项目类别:
-
资助金额:$22.55万
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财政年份:1998
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负责人:MICHAEL A BALDWIN
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依托单位:
CORE-SCIENTIFIC
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批准号:6234401
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项目类别:
-
资助金额:$20.11万
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财政年份:1997
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负责人:MICHAEL A BALDWIN
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依托单位:
SYNTHETIC AND RECOMBINANT PRP PEPTIDES AND PROTEINS
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批准号:6234399
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项目类别:
-
资助金额:$20.11万
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财政年份:1997
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负责人:MICHAEL A BALDWIN
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依托单位:
CORE--SCIENTIFIC
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批准号:6233951
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项目类别:
-
资助金额:$21.15万
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财政年份:1997
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负责人:MICHAEL A BALDWIN
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依托单位:
CORE--SCIENTIFIC
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批准号:6243574
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项目类别:
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资助金额:$16.91万
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财政年份:1997
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负责人:MICHAEL A BALDWIN
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依托单位:
海外基金