CORE--FACILITY FOR AGING RODENTS

老年啮齿动物核心设施(CFAR)提供动物和建议 希望使用动物模型来研究人的生物学的研究科学家们 衰老，衰老与疾病或治疗之间的关系 可能导致人类干预试验发展的方法 与老年人的独立性和保健有关。CFAR是 由病理学教授理查德·A·米勒博士执导 老年医学中心研究部副主任。兽医 咨询由DVM助理教授Robert Dysko博士提供 实验动物医学。购买老龄和对照大鼠和小鼠 来自NIA合同殖民地并供应给Pepper Center的收件人 试点/可行性补助金，发给希望获得 为准备OAIC或 校外支持，以及希望开始研究的知名科学家 老年病学或老年学方面的问题，他们还没有解决 外部支持。这便于接触到老啮齿动物 吸引发展中的和成熟的科学家到实验老年医学 并为他们在这个领域的初步尝试提供便利，同时 确保他们获得(核心主管)有关事项的咨询意见的时间 选择品系和物种，适当选择年龄组，以及 显性或潜伏性疾病的可能影响。核心资源也是 致力于开发新的动物模型，呈现出独特的 老龄化和老年病研究的优势。四个这样的模型 目前正在开发：(A)通过四向杂交培育的“HET”小鼠 从近亲交配的祖父母，提供一定程度的可复制的基因和 与现有变异更接近的表型异质性 在老龄化的人口中；(B)缺乏成体的WI/Hicks/CAR大鼠 生长使其特别适合于跨年龄的研究 移植(如肌肉和神经移植)；(C)MDX/MDX小鼠 在成年早期会发展成一种轻度的肌肉营养不良 这可能为晚年的近视提供了一个有用的模型；和(D) T(X；16)16Hx SPE(Mus Spretus)F1杂交鼠 有助于研究X染色体基因在衰老过程中的重新激活。 因此，CFAR为Pepper Center和其他U/M研究人员提供了 咨询实验设计，方便老年大鼠和 小鼠，以及在制造和鉴定新的啮齿动物模型方面的协助 对衰老的研究特别有用，但不可用 其他地方。

The Core Facility for Aged Rodents (CFAR) provides animals and advice for research scientists who wish to use animal models to study the biology of aging, the relationship between aging and disease, or therapeutic approaches that could lead to the development of human intervention trials relevant to the independence and health care of the elderly. CFAR is directed by Dr. Richard A. Miller, Professor of Pathology and the Associate Director for Research of the Geriatrics Center. Veterinary consultation is provided by Dr. Robert Dysko, DVM, Assistant Professor of Laboratory Animal Medicine. Aged and control rats and mice are purchased from the NIA Contract Colonies and supplied to recipients of Pepper Center Pilot/Feasibility Grants, to junior faculty scientists who wish to acquire pilot data towards the preparation of an application for OAIC or extramural support, and to established scientists who wish to begin study of a problem in geriatrics or gerontology for which they do yet have external support. This facilitated access to old rodents serves to attract developing and established scientists to experimental geriatrics and to facilitate their initial forays in this field, while at the same time ensuring that they obtain advice (from the Core Director) on matters of choice of strain and species, appropriate selection of age groups, and possible influence of overt or latent diseases. Core resources are also devoted to the development of novel animal models that present unique advantages for studies of aging and geriatric diseases. Four such models are currently under development: (a) "HET" mice, bred by a four-way cross from inbred grandparents, to provide a degree of reproducible genetic and phenotypic heterogeneity that more closely resembles the variation present in aging human populations; (b) the WI/Hicks/Car rat whose lack of adult growth makes it particularly suited for studies of cross-age transplantation (e.g. of muscle and nerve grafts); (c) the mdx/mdx mouse that develops a mild form of muscular dystrophy in early adult life and that may provide a useful model of late life myopenia; and (d) the T(X;16)16H x SPE (Mus spretus) F1 hybrid mouse, a cross-species hybrid useful for investigations of X chromosome gene reactivation in aging. CFAR thus provides Pepper Center and other U/M researchers with consultation on experimental design, facilitated access to aged rats and mice, and assistance in producing and characterizing new rodent models that are particularly useful for studies of aging and not available elsewhere.