THE PROTEIN DISEASE DATABASE OF COMMON HUMAN BODY FLUIDS

蛋白质-疾病数据库(PDD)是围绕关系数据库系统(Oracle RDBMS)构建的万维网可搜索数据库。该PDD在Lemkin P.F.等人1995年的《电泳学》16：1175；Merril C.等人的Appl.中有描述。西奥。电泳法5：49-54,1995；Lemkin P.F.等人。APPL西奥。电泳法5：55-72,1995。网页地址为http://www-lecb.ncifcrf.gov/PDD/.该项目的目标是为通常采样的人体体液中的蛋白质创建关系数据库：正常生理状态和癌症或其他疾病状态下的血浆/血清、脑脊液和尿蛋白。在过去的二十年里，已经积累了大量关于血浆、血清、脑脊液和尿蛋白变化的文献，这些变化被确定为在生理和疾病状态下的变化。虽然许多这些蛋白质的变化是通过不同于电泳法的技术测量的，也就是通过：酶、免疫分析，或者在某些情况下仅仅是与特定物质和沉降率的相互作用，这些数据可以作为确定疾病状态下蛋白质N倍浓度变化的基础。在可能的情况下，该数据库将与从每一种流体中提取的高分辨率2D电泳谱以及通过互联网可访问的基因组数据库相联系。PDD包括基于文献的数据，关于在体液(血浆/血清、尿液、脑脊液)中发现的蛋白质，相对于正常人群，这些蛋白质的浓度随着癌症和精神健康以及其他疾病状态的变化而呈现N倍的变化。我们设想，需要寻找这些类型变化的研究人员将最初使用PDD。稍后，作为预筛查的一部分，它可能会在临床上变得更有用。在预筛查中，几个标记蛋白的变化可以用来搜索PDD以寻找可能相关的疾病状况，或者检查可疑疾病是否有与其相关的蛋白质标记。我们正在收集有关体液蛋白的数据，特别是集中在癌症、肿瘤和心理健康体液标记物上。Z01 BC 10273-03-癌症预防，数据库，电泳，基因表达，基因图谱，炎症，蛋白质化学，

The Protein-Disease Database (PDD) is a World Wide Web searchable database built around a relational database system (Oracle RDBMS). The PDD is described in Lemkin P. F., et al., Electrophoresis 16: 1175, 1995; Merril C., et al., Appl. Theor. Electrophoresis 5: 49-54, 1995; Lemkin P. F. etal. Appl. Theor. Electrophoresis 5:55-72, 1995. The Web URL is http://www-lecb.ncifcrf.gov/PDD/. The goal of this project is to create relational databases for proteins in commonly sampled human body fluids: Plasma/serum, cerebrospinal fluid and urinary proteins during normal physiological and cancer or other disease states. There is a large literature accumulated over the past two decades about plasma, serum, CSF and urine protein changes that have been determined as varying in physiological and disease states. While many of these protein changes were measured by techniques other than electrophoretic, that is by: Enzymatic, immune assays, or in some cases merely interaction with specific substances and sedimentation rates, these data can be used as a basis for establishing proteins N-fold concentration changes in disease states. This database is being linked, when possible, to high resolution 2D electrophoretic protein patterns that have been derived from each of these fluids, as well as to genomic databases accessible over the Internet. The PDD includes literature- based data on proteins found in body fluids (plasma/serum, urine, CSF) which exhibit N-fold concentration changes with cancer and mental health other disease states with respect to normal populations. We envision the initial use of the PDD by researchers who need to search for these types of changes. Later, it may become more useful clinically as part of a pre-screen where changes in several marker proteins could be used to search the PDD for possible associated disease conditions - or to check a suspected disease for protein markers associated with it. We are gathering data on body fluid proteins - in particular concentrating on cancer, tumor and mental health body fluid markers. Z01 BC 10273-03 - Cancer Prevention, database, electrophoresis, gene expression, gene mapping, Inflammation, protein chemistry,