MicroArray Explorer for the data mining of expression profiles of cDNA microarra

MicroArray Explorer或MAExplorer是一个基于java的数据挖掘工具，用于跨多个微阵列杂交探索微阵列cDNA表达数据。阵列用于监测各种生理条件下的表达谱。MAExplorer可以作为Web浏览器小程序或用户计算机上的独立应用程序使用。独立应用程序可以保存和读取用户磁盘上的数据，以创建自定义数据挖掘会话。它可以读取来自各种膜和玻璃微阵列的数据，具有33P和Cy3/Cy5标记。正在添加其他数组。数据库配置是灵活的，可以将MAExplorer与其他类型的数组一起使用。数据可以在图像、散点图、直方图、表达剖面图、聚类分析等中查看和直接操作。使用“数据过滤器”可以发现有趣的克隆集，该“数据过滤器”可以找到通过各种用户指定的测试的克隆集。用户可生成过滤后的克隆报告，该报告可直接访问UniGene、GeneBank、NCI/CIT mAdb等互联网数据库。报表数据可以导出为Excel。MAExplorer帮助：1)分析单个基因的表达；2)分析基因家族和基因簇的表达；3)比较多个数组的表达式模式。数据从用户计算机上的本地文件读取或从Web阵列数据库服务器下载。本地阵列斑点定量文件可以直接从阵列扫描仪获得。或者，当数据从Web数据库服务器下载时，它可以保存（缓存）在用户的计算机上。这避免了在以后的数据分析会话中长时间启动，并允许在用户未连接到Web时分析数据。该网站http://www.lecb.ncifcrf.gov/MAExplorer使用户可以下载用于在Windows、Macintosh或Unix系统（Sun Solaris、Linux等）上运行的MAExplorer的独立版本，并提供文档和教程。MAExplorer （applet版本）可通过乳腺基因组解剖程序服务器（http://mammary.nih.gov/mgap或http://www.lecb.ncifcrf.gov/mae）访问。1999年10月1日至2000年9月30日BC 10303-01

The MicroArray Explorer or MAExplorer is a Java-based data mining tool for exploring microarray cDNA expression data across multiple microarray hybridizations. Arrays are used to monitor expression profiles under various physiological conditions. MAExplorer is available as either a Web browser applet or a stand-alone application on a user's computer. Stand-alone applications can save and read data on the user's disk for creating custom data mining sessions. It can read data derived from a variety of membrane and glass microarrays, with 33P and Cy3/Cy5 labeling. Other arrays are being added. Database configuration is flexible making it possible to use MAExplorer with other types of arrays. Data may be viewed and directly manipulated in images, scatter plots, histograms, expression profile plots, cluster analysis, etc. Interesting sets of clones may be discovered using a "data filter" that finds a set of clones passing a variety of user-specified tests. Users may generate filtered clone reports which may directly access UniGene, GeneBank, NCI/CIT mAdb and other Internet databases. Report data may be exported to Excel. MAExplorer helps: 1) analyze the expression of individual genes; 2) analyze the expression of gene families and clusters; 3) compare expression patterns for multiple arrays.Data is read from local files on a user's computer or downloaded from a Web array database server. Local array spot quantification files could be obtained directly from an array scanner. Alternatively, when data is downloaded from a Web database server it may be saved (cached) on the user's computer. This avoids long startup times in future data analysis sessions and allows analysis of the data when users are not connected to the Web. The Web site http://www.lecb.ncifcrf.gov/MAExplorer enables users to download the stand-alone version of MAExplorer for running on Windows, Macintosh or Unix systems (Sun Solaris, Linux, etc.) as well as providing documentation and tutorials.The MAExplorer (applet version) may be accessed through the Mammary Genome Anatomy Program server at http://mammary.nih.gov/mgap or http://www.lecb.ncifcrf.gov/mae. October 1, 1999 through September 30, 2000Z01 BC 10303-01