Computer Aided Two-Dimensional Electrophoretic Gel Analy

GELLAB-II软件系统http://www-lecb.ncifcrf.gov/lemkin/gellab.html，是一个探索性的数据分析系统，用于分析用UNIX语言编写的一组二维蛋白质凝胶图像。它集成了用于图像采集、处理、数据库操作、图形和统计分析的复杂子系统。它已经被应用于各种实验系统，在这些实验系统中，成百上千个未改变的蛋白质中的一个或多个蛋白质的定量和定性变化是基本的分析问题。跟踪使用这些方法检测到的变化也是该系统的一个主要属性。可以在不同的探索性数据分析条件下查看复合凝胶数据库，并且从有效的3D数据库的切片中阐明统计差异和微妙的图案。结果可以在各种表格、曲线图或衍生图像中显示，也可以通过广域网在工作站上显示。GELLAB-II的研究已经导致CRADA与CSPI/Scanalytics Inc.就一种商用系统GELLAB-II进行了技术转让，使癌症研究人员可以在廉价的Microsoft Windows PC(于1996年发布)上轻松获得这项技术。这种商业化导致了GELLAB-II技术比我们所能提供的更广泛的使用和更好的支持。 Z01公元前08381-16

The GELLAB-II software system, http://www-lecb.ncifcrf.gov/lemkin/gellab.html, is an exploratory data analysis system for the analysis of sets of 2D electrophoretic protein gel images written in UNIX. It incorporates sophisticated subsystems for image acquisition, processing, database manipulation, graphics and statistical analysis. It has been applied to a variety of experimental systems in which quantitative and qualitative changes, in one or more proteins among hundreds or thousands of unaltered proteins, is the basic analytic problem. Keeping track of changes detected using these methods is also a major attribute of the system. A composite gel database may be viewed under different exploratory data analysis conditions, and statistical differences and subtle patterns elucidated from slices of an effective 3D database. Results can be presented in a variety of tables, plots or derived images and on workstations over wide area networks. The GELLAB-II research has resulted in a technology transfer CRADA with CSPI/Scanalytics Inc., for a commercially available system GELLAB-II+, making this technology easily available to cancer researchers on inexpensive Microsoft Windows PCs (released in 1996). Such commercialization resulted in wider use and better support of the GELLAB-II technology than we could provide. Z01 BC 08381-16