EXPERIMENTAL DEPENDENCE OF BOLD MAGNETIC FIELD DEPENDENCE ON VESSELS & TISSUE

大胆的实验依赖性 磁场对容器的依赖性

• 批准号: 6314441
• 负责人: KAMIL UGURBIL
• 金额: $ 3.8万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6314441
• 关键词: bioimaging /biomedical imaging; biomedical resource; cognition; communication behavior; female; human subject; magnetic resonance imaging; male; mental disorders; nervous system; technology /technique

Concurrent with the experimental demonstrations of fMRI, calculations and experiments evaluating the vascular origin of the BOLD effect were performed by our group. Calculations previously demonstrated that the BOLD phenomenon has two components, one dependent linearly and other quadratically on the main magnetic field magnitude (Bo) arising from macro-and microvasculature, respectively. Consistent with these theoretical and experimental studies, a study we performed in the last funding period demonstrated that the BOLD contrast-to-noise ratio was found to depend on magnetic field strength less than linearly in voxels containing vessels larger than the voxel itself and greater than linearly in voxels containing a mixture of capillaries and veins/venules with diameter less than that of the voxel. The experimental result in this study further demonstrates that a high magnetic field provides improved contrast for fMRI and more emphasis to more specific areas containing small vessels.

在功能磁共振成像实验演示的同时， 计算和实验评估血管起源的 BOLD效应由我们组完成。 以前的计算 证明BOLD现象有两个组成部分，一个是 与主磁场成线性或二次关系 幅度（Bo）分别由大血管和微血管产生。 与这些理论和实验研究一致，我们进行了一项研究， 在上一个供资期间进行的研究表明， 对比度噪声比被发现依赖于磁场强度 在包含大于体素的血管的体素中小于线性 本身，并大于线性体素包含的混合物 毛细血管和静脉/小静脉直径小于 体素 本研究的实验结果进一步证明 高磁场为功能磁共振成像提供了更好的对比度， 更加重视包含小型船只的更具体区域。