Small Animal 11.75 Tesla Magnetic Resonance Scanner

小动物11.75特斯拉磁共振扫描仪

• 批准号: 6503261
• 负责人: JOSEPH J. H. ACKERMAN
• 金额: $ 200万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6503261
• 关键词: biomedical equipment purchase; laboratory mouse; magnetic resonance imaging; noninvasive diagnosis

DESCRIPTION (provided by applicant): Small laboratory animal models such as mice, rats and hamsters are widely used throughout the biomedical research community at Washington University (WU) in St. Louis and other scientific institutions. With the recent revolution in molecular biology, transgenic laboratory animal models - in particular mice - have become an indispensable part of the biomedical research armamentarium. The identification and development of methods for analyzing and evaluating the characteristics of interest within animal models remains a significant challenge. This is especially true for longitudinal studies, in which members of a sample population are followed over an extended period of time. Clearly, invasive and/or destructive procedures - especially those that require sacrifice of the subject - are incompatible with such studies. Under these circumstances, nondestructive imaging procedures, such as those offered by magnetic resonance imaging (MRI), are especially valuable. This proposal from the Biomedical Magnetic Resonance Laboratory (BMRL) at WU requests funds to purchase an 11.75 tesla small animal MRI scanner. The BMRL supports resources at the forefront of imaging science through its two 4.7T small-animal MRI scanners. However, its user base of leading scientists, representing a diverse range of biological and biophysical disciplines, has requirements that can only be met through the attributes an ultra high field scanner. The associated improvements in signal-to-noise ratio and spectral dispersion provide important advantages for small animal MRI and, in particular, for the imaging of mice. This proposal provides documentation of need, past imaging performance, organizational and training competence, and institutional commitment.

描述(由申请人提供)：小鼠、大鼠和仓鼠等小型实验动物模型广泛应用于圣路易斯华盛顿大学(WU)和其他科学机构的生物医学研究社区。随着最近分子生物学的革命，转基因实验动物模型--特别是小鼠--已经成为生物医学研究机构不可或缺的一部分。确定和发展用于分析和评估动物模型中的兴趣特征的方法仍然是一个巨大的挑战。这对于纵向研究尤其如此，在纵向研究中，样本总体的成员被跟踪一段较长的时间。显然，侵入性和/或破坏性程序--特别是那些需要牺牲受试者的程序--与此类研究不相容。在这种情况下，非破坏性成像程序，如磁共振成像(MRI)提供的程序，特别有价值。这份来自吴的生物医学磁共振实验室(BMRL)的提案要求资金购买11.75Tesla小动物MRI扫描仪。BMRL通过其两台4.7T小型动物核磁共振扫描仪为成像科学前沿的资源提供支持。然而，它的用户基础是代表各种生物学和生物物理学科的顶尖科学家，他们的要求只有通过超高场扫描仪的属性才能满足。信噪比和光谱色散的相关改善为小动物MRI，特别是小鼠的成像提供了重要的优势。该建议书提供了关于需求、过去的成像绩效、组织和培训能力以及机构承诺的文件。