Endosomal sorting of amyloid precursor protein in Alzheimer's disease

阿尔茨海默病中淀粉样前体蛋白的内体分选

• 批准号: nhmrc : 1058734
• 负责人: A/Pr Brett Collins
• 金额: $ 57.25万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/endosomal-sorting-amyloid-alzheimers-disease/454699
• 关键词: Endosomal; sorting; amyloid; precursor; protein

Alzheimer's Disease is a progressive neurological disorder and is the most common cause of dementia. Effective treatments are desperately needed, but none are currently available. The toxic amyloid peptide A? is central to disease pathology and is derived from breakdown of the Alzheimer’s amyloid precursor protein (APP). In this project we will examine the interactions between APP and the molecular machinery that controls its location in the cell and subsequent degradation.

阿尔茨海默病是一种进行性神经系统疾病，是痴呆症最常见的原因。迫切需要有效的治疗方法，但目前还没有。有毒的淀粉样肽A？是疾病病理学的核心，来源于阿尔茨海默氏淀粉样前体蛋白（APP）的分解。在这个项目中，我们将研究APP和控制其在细胞中的位置和随后的降解的分子机制之间的相互作用。