Sorting out the synapse: the role of intracellular trafficking in NMDA receptor homeostasis

整理突触：细胞内运输在 NMDA 受体稳态中的作用

• 批准号: nhmrc : GNT1099114
• 负责人: A/Pr Brett Collins
• 金额: $ 63.2万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/sorting-synapse-role-receptor-homeostasis/1346032
• 关键词: Sorting; out; synapse; role; intracellular

When the normal levels of cell surface proteins in neurons are reduced this can lead to a variety of debilitating neurodegenerative and neuronal diseases. These levels are maintained by organelles inside the neuron called endosomes. In this project we will examine how cell surface receptors required for synapse formation are transported through endosomes by a protein machine called retromer, which is important in both Alzheimer’s and Parkinson’s disease.

当神经元中细胞表面蛋白的正常水平降低时，这可导致多种使人衰弱的神经变性和神经元疾病。这些水平由神经元内称为内体的细胞器维持。在这个项目中，我们将研究突触形成所需的细胞表面受体如何通过一种称为retromer的蛋白质机器通过内体转运，这在阿尔茨海默氏症和帕金森氏症中都很重要。