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Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale

Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale
揭示纳米级 Munc18-1 和 α-突触核蛋白共聚集的起源
批准号:
nhmrc : 1139316
负责人:
A/Pr Brett Collins
金额:
$41.92万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31

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中文摘要
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英文摘要
Our recent work on Munc18-1 mutations leading to a severe form of human early infantile epileptic encephalopathy (EIEE) led us to uncover a critical role for Munc18-1 in controlling the formation of toxic protein aggregates containing ?-Synuclein. Targeting the Munc18-1 ?-Synuclein interaction may have therapeutic values not only for EIEE but also for other neurological diseases characterised by protein aggregations.
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Peripheral Membrane Proteins In Health And Disease
  • 批准号:
    nhmrc : GNT1136021
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $64.02万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Brett Collins
  • 依托单位:
Regulation of glutamate receptor trafficking by the calcium- and lipid-binding protein, copine-6
  • 批准号:
    nhmrc : 1138452
  • 项目类别:
    Project Grants
  • 资助金额:
    $37.1万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Brett Collins
  • 依托单位:
Regulation of glutamate receptor trafficking by the calcium- and lipid-binding protein, copine-6
  • 批准号:
    nhmrc : GNT1138452
  • 项目类别:
    Project Grants
  • 资助金额:
    $54.87万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Brett Collins
  • 依托单位:
Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale
  • 批准号:
    nhmrc : GNT1139316
  • 项目类别:
    Project Grants
  • 资助金额:
    $62.0万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Brett Collins
  • 依托单位:
国内基金
海外基金
Lagrangian origin of geometric approaches to scattering amplitudes
  • 批准号:
    24ZR1450600
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2024
  • 负责人:
    ALEXANDER OCHIROV
  • 依托单位:
The formation and evolution of planetary systems in dense star clusters
  • 批准号:
    11043007
  • 项目类别:
    专项基金项目
  • 资助金额:
    10.0万元
  • 批准年份:
    2010
  • 负责人:
    柯文采
  • 依托单位: