Unraveling the dynamic Munc18a:Syntaxin1 interaction required for neurotransmission

揭示神经传递所需的动态 Munc18a:Syntaxin1 相互作用

• 批准号: nhmrc : GNT1080995
• 负责人: A/Pr Brett Collins
• 金额: $ 65.35万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/unraveling-dynamic-munc18asyntaxin1-required-neurotransmission/1345379
• 关键词: Unraveling; dynamic; Munc18a; Syntaxin1; interaction

Membrane trafficking, the topic of the 2013 Nobel prize in Medicine, is required for delivery of cellular cargo. This research will investigate the interactions and structures of proteins from the neuronal membrane trafficking system. Understanding how this system operates will expand our knowledge of processes fundamental to learning and memory and may ultimately lead to development of selective therapeutics for treating a range of diseases.

2013年诺贝尔医学奖的主题是膜运输，它是细胞运输所必需的。这项研究将研究神经元膜运输系统中蛋白质的相互作用和结构。了解这个系统如何运作将扩大我们对学习和记忆过程的基本知识，并可能最终导致治疗一系列疾病的选择性疗法的发展。