Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale
Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale
批准号:
nhmrc : GNT1139316
负责人:
A/Pr Brett Collins
金额:
$62.0万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 --
中文摘要
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英文摘要
Our recent work on Munc18-1 mutations leading to a severe form of human early infantile epileptic encephalopathy (EIEE) led us to uncover a critical role for Munc18-1 in controlling the formation of toxic protein aggregates containing α-Synuclein. Targeting the Munc18-1 α-Synuclein interaction may have therapeutic values not only for EIEE but also for other neurological diseases characterised by protein aggregations.
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会议论文
Peripheral Membrane Proteins In Health And Disease
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批准号:nhmrc : GNT1136021
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项目类别:Research Fellowships
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资助金额:$64.02万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Regulation of glutamate receptor trafficking by the calcium- and lipid-binding protein, copine-6
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批准号:nhmrc : 1138452
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项目类别:Project Grants
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资助金额:$37.1万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Regulation of glutamate receptor trafficking by the calcium- and lipid-binding protein, copine-6
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批准号:nhmrc : GNT1138452
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项目类别:Project Grants
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资助金额:$54.87万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
How do you SNARE a synaptic vesicle?
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批准号:nhmrc : GNT1138083
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项目类别:Project Grants
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资助金额:$65.44万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Peripheral Membrane Proteins In Health And Disease
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批准号:nhmrc : 1136021
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项目类别:Research Fellowships
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资助金额:$43.29万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
How do you SNARE a synaptic vesicle?
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批准号:nhmrc : 1138083
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项目类别:Project Grants
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资助金额:$44.25万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale
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批准号:nhmrc : 1139316
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项目类别:Project Grants
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资助金额:$41.92万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Sorting out the synapse: the role of intracellular trafficking in NMDA receptor homeostasis
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批准号:nhmrc : GNT1099114
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项目类别:Project Grants
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资助金额:$63.2万
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财政年份:2016
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负责人:A/Pr Brett Collins
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依托单位:
Sorting out the synapse: the role of intracellular trafficking in NMDA receptor homeostasis
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批准号:nhmrc : 1099114
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项目类别:Project Grants
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资助金额:$43.34万
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财政年份:2016
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负责人:A/Pr Brett Collins
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依托单位:
Unraveling the dynamic Munc18a:Syntaxin1 interaction required for neurotransmission
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批准号:nhmrc : GNT1080995
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项目类别:Project Grants
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资助金额:$65.35万
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财政年份:2015
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负责人:A/Pr Brett Collins
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依托单位:
Unraveling the dynamic Munc18a:Syntaxin1 interaction required for neurotransmission
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批准号:nhmrc : 1080995
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项目类别:Project Grants
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资助金额:$44.98万
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财政年份:2015
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负责人:A/Pr Brett Collins
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依托单位:
Peripheral membrane proteins in health and disease
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批准号:nhmrc : GNT1061574
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项目类别:Career Development Fellowships
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资助金额:$44.78万
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财政年份:2014
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负责人:A/Pr Brett Collins
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依托单位:
Peripheral membrane proteins in health and disease
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批准号:nhmrc : 1061574
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项目类别:Career Development Fellowships
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资助金额:$31.28万
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财政年份:2014
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负责人:A/Pr Brett Collins
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依托单位:
Endosomal sorting of amyloid precursor protein in Alzheimer's disease
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批准号:nhmrc : 1058734
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项目类别:Project Grants
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资助金额:$57.25万
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财政年份:2014
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负责人:A/Pr Brett Collins
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依托单位:
Uncover how Myosin-6 underpins the Ca2+-dependent recruitment of secretory vesicles to the cortical actin network
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批准号:nhmrc : 1058769
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项目类别:Project Grants
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资助金额:$37.29万
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财政年份:2014
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负责人:A/Pr Brett Collins
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依托单位:
Unravelling Munc18 dual function in exocytosis
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批准号:nhmrc : 1044014
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项目类别:Project Grants
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资助金额:$34.4万
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财政年份:2013
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负责人:A/Pr Brett Collins
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依托单位:
Understanding how membrane trafficking controls the levels of Alzheimer's disease causing A? peptides
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批准号:nhmrc : 1042082
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项目类别:Project Grants
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资助金额:$31.93万
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财政年份:2013
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负责人:A/Pr Brett Collins
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依托单位:
The role of intracellular protein trafficking in Alzheimer's disease
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批准号:nhmrc : 1025538
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项目类别:Project Grants
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资助金额:$0.0万
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财政年份:2012
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负责人:A/Pr Brett Collins
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依托单位:
Control of neurosecretion by Munc18
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批准号:nhmrc : 631349
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项目类别:NHMRC Project Grants
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资助金额:$32.85万
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财政年份:2010
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负责人:A/Pr Brett Collins
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依托单位:
Retromer based Endosome Trafficking
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批准号:nhmrc : 511072
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项目类别:NHMRC Project Grants
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资助金额:$32.72万
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财政年份:2008
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负责人:A/Pr Brett Collins
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依托单位:
国内基金
海外基金
Lagrangian origin of geometric approaches to scattering amplitudes
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批准号:24ZR1450600
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项目类别:省市级项目
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资助金额:--
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批准年份:2024
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负责人:ALEXANDER OCHIROV
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依托单位:
The formation and evolution of planetary systems in dense star clusters
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批准号:11043007
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项目类别:专项基金项目
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资助金额:10.0万元
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批准年份:2010
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负责人:柯文采
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依托单位: