Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale

揭示纳米级 Munc18-1 和 α-突触核蛋白共聚集的起源

• 批准号: nhmrc : GNT1139316
• 负责人: A/Pr Brett Collins
• 金额: $ 62万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/unveiling-origin-munc18-aggregation-nanoscale/1348214
• 关键词: Unveiling; origin; Munc18; alpha; synuclein

Our recent work on Munc18-1 mutations leading to a severe form of human early infantile epileptic encephalopathy (EIEE) led us to uncover a critical role for Munc18-1 in controlling the formation of toxic protein aggregates containing α-Synuclein. Targeting the Munc18-1 α-Synuclein interaction may have therapeutic values not only for EIEE but also for other neurological diseases characterised by protein aggregations.

我们最近对Munc 18 -1突变导致严重形式的人类早期婴儿癫痫性脑病（EIEE）的研究，使我们发现Munc 18 -1在控制含有α-突触核蛋白的毒性蛋白聚集体形成中的关键作用。靶向Munc 18 -1 α-突触核蛋白相互作用可能不仅对EIEE具有治疗价值，而且对以蛋白质聚集为特征的其他神经系统疾病也具有治疗价值。