Unravelling Munc18 dual function in exocytosis

揭示 Munc18 在胞吐作用中的双重功能

• 批准号: nhmrc : 1044014
• 负责人: A/Pr Brett Collins
• 金额: $ 34.4万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/unravelling-munc18-dual-function-exocytosis/111624
• 关键词: Unravelling; Munc18; dual; function; exocytosis

Neuronal communication relies on the process of exocytosis by which neurons release a neurotransmitter. Exocytosis is critical for the simplest muscle movement to complex tasks such as learning and memory, and is altered in several neurodegenerative pathologies. We will investigate how the protein Munc18 controls exocytosis. This research will be important for understanding how neurons communicate in health and disease and will be relevant to other processes such as insulin release in diabetes.

神经元的通讯依赖于胞吐作用，神经元通过胞吐作用释放神经递质。胞吐作用对于最简单的肌肉运动到复杂的任务（如学习和记忆）至关重要，并且在几种神经退行性病变中发生改变。我们将研究蛋白质Munc18如何控制胞吐作用。这项研究对于了解神经元在健康和疾病中如何交流非常重要，并且与糖尿病中的胰岛素释放等其他过程相关。