Uncover how Myosin-6 underpins the Ca2+-dependent recruitment of secretory vesicles to the cortical actin network

揭示 Myosin-6 如何支持 Ca2 依赖性分泌囊泡向皮质肌动蛋白网络的募集

• 批准号: nhmrc : 1058769
• 负责人: A/Pr Brett Collins
• 金额: $ 37.29万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/uncover-myosin-6-actin-network/454702
• 关键词: Uncover; how; Myosin; underpins; Ca2+

Neuronal communication relies on the process of exocytosis by which neurons release a neurotransmitter. Exocytosis underpins processes such as the simplest muscle movement to complex tasks such as learning and memory, and is altered in several neurodegenerative pathologies. We will investigate how the protein Myosin-6 controls exocytosis. This research will be important for understanding how neurons communicate in health and disease and will be relevant to other processes such as insulin release in diabetes.

神经元通讯依赖于神经元释放神经递质的胞吐作用过程。胞吐作用是从最简单的肌肉运动到学习和记忆等复杂任务等过程的基础，并且在几种神经退行性疾病中发生改变。我们将研究肌球蛋白 6 蛋白如何控制胞吐作用。这项研究对于了解神经元如何在健康和疾病中进行交流非常重要，并且与其他过程（例如糖尿病中的胰岛素释放）相关。