Peripheral membrane proteins in health and disease

外周膜蛋白在健康和疾病中的作用

• 批准号: nhmrc : GNT1061574
• 负责人: A/Pr Brett Collins
• 金额: $ 44.78万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/peripheral-membrane-proteins-health-disease/1344773
• 关键词: Peripheral; membrane; proteins; health; disease

Peripheral membrane proteins are critical for processes such as cell transport, signaling, neurosecretion and development. As such, their dysfunction can lead to many debilitating diseases including cancer, inflammation and neurodegeneration. This project will establish fundamental new knowledge about how peripheral membrane proteins regulate cell function, how their perturbation or mutation results in human disease, and will inform efforts to target them for future therapeutic outcomes.

外周膜蛋白对细胞运输、信号传导、神经分泌和发育等过程至关重要。因此，它们的功能障碍会导致许多使人衰弱的疾病，包括癌症、炎症和神经变性。该项目将建立关于外周膜蛋白如何调节细胞功能，它们的扰动或突变如何导致人类疾病的基本新知识，并将为未来治疗结果的目标提供信息。