Peripheral Membrane Proteins In Health And Disease
Peripheral Membrane Proteins In Health And Disease
批准号:
nhmrc : 1136021
负责人:
A/Pr Brett Collins
金额:
$43.29万
依托单位国家:
澳大利亚
项目类别:
Research Fellowships
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2022-12-31
中文摘要
外周膜蛋白对于细胞转运、信号传导、神经分泌和发育等过程至关重要。因此,它们的功能障碍可能导致许多使人衰弱的疾病,包括癌症、炎症和神经变性。该项目将建立关于外周膜蛋白如何调节细胞功能的基本新知识,它们的扰动或突变如何导致人类疾病,并将为未来的治疗结果提供信息。
英文摘要
Peripheral membrane proteins are critical for processes such as cell transport, signaling, neurosecretion and development. As such, their dysfunction can lead to many debilitating diseases including cancer, inflammation and neurodegeneration. This project will establish fundamental new knowledge about how peripheral membrane proteins regulate cell function, how their perturbation or mutation results in human disease, and will inform efforts to target them for future therapeutic outcomes.
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会议论文
Peripheral Membrane Proteins In Health And Disease
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批准号:nhmrc : GNT1136021
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项目类别:Research Fellowships
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资助金额:$64.02万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Regulation of glutamate receptor trafficking by the calcium- and lipid-binding protein, copine-6
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批准号:nhmrc : 1138452
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项目类别:Project Grants
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资助金额:$37.1万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Regulation of glutamate receptor trafficking by the calcium- and lipid-binding protein, copine-6
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批准号:nhmrc : GNT1138452
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项目类别:Project Grants
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资助金额:$54.87万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale
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批准号:nhmrc : GNT1139316
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项目类别:Project Grants
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资助金额:$62.0万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
How do you SNARE a synaptic vesicle?
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批准号:nhmrc : GNT1138083
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项目类别:Project Grants
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资助金额:$65.44万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
How do you SNARE a synaptic vesicle?
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批准号:nhmrc : 1138083
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项目类别:Project Grants
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资助金额:$44.25万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale
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批准号:nhmrc : 1139316
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项目类别:Project Grants
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资助金额:$41.92万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Sorting out the synapse: the role of intracellular trafficking in NMDA receptor homeostasis
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批准号:nhmrc : GNT1099114
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项目类别:Project Grants
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资助金额:$63.2万
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财政年份:2016
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负责人:A/Pr Brett Collins
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依托单位:
Sorting out the synapse: the role of intracellular trafficking in NMDA receptor homeostasis
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批准号:nhmrc : 1099114
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项目类别:Project Grants
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资助金额:$43.34万
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财政年份:2016
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负责人:A/Pr Brett Collins
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依托单位:
Unraveling the dynamic Munc18a:Syntaxin1 interaction required for neurotransmission
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批准号:nhmrc : GNT1080995
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项目类别:Project Grants
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资助金额:$65.35万
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财政年份:2015
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负责人:A/Pr Brett Collins
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依托单位:
Unraveling the dynamic Munc18a:Syntaxin1 interaction required for neurotransmission
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批准号:nhmrc : 1080995
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项目类别:Project Grants
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资助金额:$44.98万
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财政年份:2015
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负责人:A/Pr Brett Collins
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依托单位:
Peripheral membrane proteins in health and disease
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批准号:nhmrc : GNT1061574
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项目类别:Career Development Fellowships
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资助金额:$44.78万
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财政年份:2014
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负责人:A/Pr Brett Collins
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依托单位:
Peripheral membrane proteins in health and disease
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批准号:nhmrc : 1061574
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项目类别:Career Development Fellowships
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资助金额:$31.28万
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财政年份:2014
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负责人:A/Pr Brett Collins
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依托单位:
Endosomal sorting of amyloid precursor protein in Alzheimer's disease
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批准号:nhmrc : 1058734
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项目类别:Project Grants
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资助金额:$57.25万
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财政年份:2014
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负责人:A/Pr Brett Collins
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依托单位:
Uncover how Myosin-6 underpins the Ca2+-dependent recruitment of secretory vesicles to the cortical actin network
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批准号:nhmrc : 1058769
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项目类别:Project Grants
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资助金额:$37.29万
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财政年份:2014
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负责人:A/Pr Brett Collins
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依托单位:
Unravelling Munc18 dual function in exocytosis
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批准号:nhmrc : 1044014
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项目类别:Project Grants
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资助金额:$34.4万
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财政年份:2013
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负责人:A/Pr Brett Collins
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依托单位:
Understanding how membrane trafficking controls the levels of Alzheimer's disease causing A? peptides
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批准号:nhmrc : 1042082
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项目类别:Project Grants
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资助金额:$31.93万
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财政年份:2013
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负责人:A/Pr Brett Collins
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依托单位:
The role of intracellular protein trafficking in Alzheimer's disease
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批准号:nhmrc : 1025538
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项目类别:Project Grants
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资助金额:$0.0万
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财政年份:2012
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负责人:A/Pr Brett Collins
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依托单位:
Control of neurosecretion by Munc18
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批准号:nhmrc : 631349
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项目类别:NHMRC Project Grants
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资助金额:$32.85万
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财政年份:2010
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负责人:A/Pr Brett Collins
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依托单位:
Retromer based Endosome Trafficking
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批准号:nhmrc : 511072
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项目类别:NHMRC Project Grants
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资助金额:$32.72万
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财政年份:2008
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负责人:A/Pr Brett Collins
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依托单位:
海外基金