The role of intracellular protein trafficking in Alzheimer's disease
The role of intracellular protein trafficking in Alzheimer's disease
批准号:
nhmrc : 1025538
负责人:
A/Pr Brett Collins
金额:
$0.0万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2013-12-31
中文摘要
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英文摘要
Alzheimer’s disease (AD) is a progressive neurological disorder and is the most common cause of dementia. The development of therapies must be preceded by a thorough understanding of the molecular processes that underpin the disease. In this project we will examine the interactions between the Alzheimer’s precursor protein (APP) and the molecular machinery that controls its intracellular localization and breakdown to the toxic A? peptide that is central to disease pathology.
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会议论文
Peripheral Membrane Proteins In Health And Disease
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批准号:nhmrc : GNT1136021
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项目类别:Research Fellowships
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资助金额:$64.02万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Regulation of glutamate receptor trafficking by the calcium- and lipid-binding protein, copine-6
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批准号:nhmrc : 1138452
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项目类别:Project Grants
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资助金额:$37.1万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Regulation of glutamate receptor trafficking by the calcium- and lipid-binding protein, copine-6
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批准号:nhmrc : GNT1138452
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项目类别:Project Grants
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资助金额:$54.87万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale
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批准号:nhmrc : GNT1139316
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项目类别:Project Grants
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资助金额:$62.0万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
How do you SNARE a synaptic vesicle?
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批准号:nhmrc : GNT1138083
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项目类别:Project Grants
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资助金额:$65.44万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Peripheral Membrane Proteins In Health And Disease
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批准号:nhmrc : 1136021
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项目类别:Research Fellowships
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资助金额:$43.29万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
How do you SNARE a synaptic vesicle?
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批准号:nhmrc : 1138083
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项目类别:Project Grants
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资助金额:$44.25万
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财政年份:2018
-
负责人:A/Pr Brett Collins
-
依托单位:
Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale
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批准号:nhmrc : 1139316
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项目类别:Project Grants
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资助金额:$41.92万
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财政年份:2018
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负责人:A/Pr Brett Collins
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依托单位:
Sorting out the synapse: the role of intracellular trafficking in NMDA receptor homeostasis
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批准号:nhmrc : GNT1099114
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项目类别:Project Grants
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资助金额:$63.2万
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财政年份:2016
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负责人:A/Pr Brett Collins
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依托单位:
Sorting out the synapse: the role of intracellular trafficking in NMDA receptor homeostasis
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批准号:nhmrc : 1099114
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项目类别:Project Grants
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资助金额:$43.34万
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财政年份:2016
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负责人:A/Pr Brett Collins
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依托单位:
Unraveling the dynamic Munc18a:Syntaxin1 interaction required for neurotransmission
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批准号:nhmrc : GNT1080995
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项目类别:Project Grants
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资助金额:$65.35万
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财政年份:2015
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负责人:A/Pr Brett Collins
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依托单位:
Unraveling the dynamic Munc18a:Syntaxin1 interaction required for neurotransmission
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批准号:nhmrc : 1080995
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项目类别:Project Grants
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资助金额:$44.98万
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财政年份:2015
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负责人:A/Pr Brett Collins
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依托单位:
Peripheral membrane proteins in health and disease
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批准号:nhmrc : GNT1061574
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项目类别:Career Development Fellowships
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资助金额:$44.78万
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财政年份:2014
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负责人:A/Pr Brett Collins
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依托单位:
Peripheral membrane proteins in health and disease
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批准号:nhmrc : 1061574
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项目类别:Career Development Fellowships
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资助金额:$31.28万
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财政年份:2014
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负责人:A/Pr Brett Collins
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依托单位:
Endosomal sorting of amyloid precursor protein in Alzheimer's disease
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批准号:nhmrc : 1058734
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项目类别:Project Grants
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资助金额:$57.25万
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财政年份:2014
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负责人:A/Pr Brett Collins
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依托单位:
Uncover how Myosin-6 underpins the Ca2+-dependent recruitment of secretory vesicles to the cortical actin network
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批准号:nhmrc : 1058769
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项目类别:Project Grants
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资助金额:$37.29万
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财政年份:2014
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负责人:A/Pr Brett Collins
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依托单位:
Unravelling Munc18 dual function in exocytosis
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批准号:nhmrc : 1044014
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项目类别:Project Grants
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资助金额:$34.4万
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财政年份:2013
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负责人:A/Pr Brett Collins
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依托单位:
Understanding how membrane trafficking controls the levels of Alzheimer's disease causing A? peptides
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批准号:nhmrc : 1042082
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项目类别:Project Grants
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资助金额:$31.93万
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财政年份:2013
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负责人:A/Pr Brett Collins
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依托单位:
Control of neurosecretion by Munc18
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批准号:nhmrc : 631349
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项目类别:NHMRC Project Grants
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资助金额:$32.85万
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财政年份:2010
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负责人:A/Pr Brett Collins
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依托单位:
Retromer based Endosome Trafficking
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批准号:nhmrc : 511072
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项目类别:NHMRC Project Grants
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资助金额:$32.72万
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财政年份:2008
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负责人:A/Pr Brett Collins
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依托单位:
国内基金
海外基金
TAG1/APP信号通路调控的miRNA及其在神经前体细胞增殖和分化中的作用机制
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批准号:31171313
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项目类别:面上项目
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资助金额:60.0万元
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批准年份:2011
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负责人:马全红
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依托单位:
吸入性全身麻醉药致发育神经元毒性的受体-细胞内钙稳态阶段特异性机制及干预研究
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批准号:30772086
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项目类别:面上项目
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资助金额:30.0万元
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批准年份:2007
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负责人:罗爱林
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依托单位: