LOW RESOLUTION DATA COLLECTION OF YEAST RNA POLYMERASE II (POL II)
LOW RESOLUTION DATA COLLECTION OF YEAST RNA POLYMERASE II (POL II)
批准号:
6586562
负责人:
PETER R DAVID
金额:
$14.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-03-01 至 2003-02-28
中文摘要
我们最近获得了高分辨率的三维图像
Pol II晶体的原子分辨率衍射。 我们现在
追求改性晶体,包括紧密结合抑制剂,
与DNA和DNA/RNA三元复合物的共复合物作为简单的途径,
重原子衍生物 我们已经改进了我们的水晶,
限制30 E为解冻晶体优于3.5 E对我们最近
使用快速冷冻运行,并试图提高纯度,
降低蛋白质的镶嵌性。 与此同时,我们正试图
获得最低分辨率反射,用于直接定相
蛋白
英文摘要
We have recently obtained high resolution three dimensional
crystals of Pol II at atomic resolution diffraction. We are now
pursuing modified crystals, including a tight binding inhibitor and
cocomplexes with DNA and DNA/RNA ternary complexes as simple routes to
heavy atom derivatives. We have improved our crystals from an earlier
limit of 30 E for unfrozen crystals to better than 3.5 E on our recent
run using flash freezing and are attempting to improve the purity of
the protein for lower mosaicity. Simultaneously, we are attempting to
obtain the lowest resolution reflections for a direct phasing of the
protein.
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CRYSTAL STRUCTURE OF YEAST RNA POLYMERASE II
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批准号:6658471
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项目类别:
-
资助金额:$14.32万
-
财政年份:2002
-
负责人:PETER R DAVID
-
依托单位:
LOW RESOLUTION YEAST RNA POLYMERASE DATA COLLECTION
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批准号:6586522
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项目类别:
-
资助金额:$14.32万
-
财政年份:2002
-
负责人:PETER R DAVID
-
依托单位:
LOW RESOLUTION YEAST RNA POLYMERASE DATA COLLECTION
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批准号:6658489
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项目类别:
-
资助金额:$14.32万
-
财政年份:2002
-
负责人:PETER R DAVID
-
依托单位:
LOW RESOLUTION DATA COLLECTION OF YEAST RNA POLYMERASE II (POL II)
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批准号:6658529
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项目类别:
-
资助金额:$14.32万
-
财政年份:2002
-
负责人:PETER R DAVID
-
依托单位:
CRYSTAL STRUCTURE OF YEAST RNA POLYMERASE II SMALL ANGLE DATA
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批准号:6658737
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项目类别:
-
资助金额:$14.32万
-
财政年份:2002
-
负责人:PETER R DAVID
-
依托单位:
CRYSTAL STRUCTURE OF YEAST RNA POLYMERASE II SMALL ANGLE DATA
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批准号:6586770
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项目类别:
-
资助金额:$14.32万
-
财政年份:2002
-
负责人:PETER R DAVID
-
依托单位:
CRYSTAL STRUCTURE OF YEAST RNA POLYMERASE II
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批准号:6586504
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项目类别:
-
资助金额:$14.32万
-
财政年份:2002
-
负责人:PETER R DAVID
-
依托单位:
CRYSTAL STRUCTURE OF YEAST RNA POLYMERASE II SMALL ANGLE DATA
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批准号:6437688
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项目类别:
-
资助金额:$14.32万
-
财政年份:2001
-
负责人:PETER R DAVID
-
依托单位:
LOW RESOLUTION YEAST RNA POLYMERASE DATA COLLECTION
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批准号:6437440
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项目类别:
-
资助金额:$14.32万
-
财政年份:2001
-
负责人:PETER R DAVID
-
依托单位:
CRYSTAL STRUCTURE OF YEAST RNA POLYMERASE II
-
批准号:6437422
-
项目类别:
-
资助金额:$14.32万
-
财政年份:2001
-
负责人:PETER R DAVID
-
依托单位:
LOW RESOLUTION DATA COLLECTION OF YEAST RNA POLYMERASE II (POL II)
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批准号:6437480
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项目类别:
-
资助金额:$14.32万
-
财政年份:2001
-
负责人:PETER R DAVID
-
依托单位:
STRUCTURE OF YEAST RNA POLYMERASE II
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批准号:6119380
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项目类别:
-
资助金额:$0.0万
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财政年份:1999
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负责人:PETER R DAVID
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依托单位:
CRYSTAL STRUCTURE OF YEAST RNA POLYMERASE II
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批准号:6119356
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项目类别:
-
资助金额:$0.0万
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财政年份:1999
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负责人:PETER R DAVID
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依托单位:
CRYSTAL STRUCTURE OF YEAST RNA POLYMERASE II SMALL ANGLE DATA
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批准号:6322172
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项目类别:
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资助金额:$0.0万
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财政年份:1999
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负责人:PETER R DAVID
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依托单位:
STRUCTURE OF YEAST RNA POLYMERASE II
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批准号:6119576
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项目类别:
-
资助金额:$0.0万
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财政年份:1999
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负责人:PETER R DAVID
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依托单位:
CRYSTAL STRUCTURE OF YEAST RNA POLYMERASE II SMALL ANGLE DATA
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批准号:6250895
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项目类别:
-
资助金额:$0.42万
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财政年份:1997
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负责人:PETER R DAVID
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依托单位:
LOW RESOLUTION YEAST RNA POLYMERASE DATA COLLECTION
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批准号:6250603
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项目类别:
-
资助金额:$0.42万
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财政年份:1997
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负责人:PETER R DAVID
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依托单位:
LOW RESOLUTION DATA COLLECTION OF YEAST RNA POLYMERASE II (POL II)
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批准号:6250653
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项目类别:
-
资助金额:$0.42万
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财政年份:1997
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负责人:PETER R DAVID
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依托单位:
CRYSTAL STRUCTURE OF YEAST RNA POLYMERASE II
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批准号:6250607
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项目类别:
-
资助金额:$0.42万
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财政年份:1997
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负责人:PETER R DAVID
-
依托单位:
LOW RESOLUTION DATA COLLECTION OF YEAST RNA POLYMERASE II (POL II)
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批准号:5222676
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:PETER R DAVID
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依托单位:--
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