Oro-facial non Contact Thermal Stimulator

口面部非接触式热刺激器

• 批准号: 7160634
• 负责人: Mikhail I. Nemenov
• 金额: $ 11.48万
• 依托单位: LASMED, LLC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-11 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7160634
• 关键词: human; lasers; lighting; pain; skin

DESCRIPTION (provided by applicant): The goal of this Phase I SBIR is to design, develop, test and validate a rodent behavioral thermal stimulator that allows differential assessment of facial and intra-orally-located nociceptors. Currently no tool is able to perform facial or intra-oral thermal nociceptive mapping in animals or humans. For example, the normal white light radiant thermal stimulus delivered by a projector bulb would provide a too bright visual cue for reliable testing. The well-known Hargreaves plantar foot stimulation device is not fiber type selective and is impractical for use in the trigeminal area. Further understanding of the locations and properties of facial nociceptors is important for probing preclinical models of oro-facial pain and neuropathies and analgesic manipulations directed at the trigeminal system. The development of the infra red laser diode stimulator could lead to a clinical research tool of significant importance for testing sensory abnormalities in patients with oro-facial pain disorders as well as drug validation and discovery. Investigators plan to test the oro-facial area of animals in Phase I. In Phase II, investigators plan to proceed with testing oro-facial areas in normal human volunteers and in patients and developing diagnostic criteria of oro-facial located naturopathic pain. Investigators will design, build and test an oro-facial infra red laser diode thermal stimulator that (A) will deliver collimated light to produce heat in skin, (B) avoid irritation of eyes for humans and animals, (C) allow flexibility in positioning and distance, (D) will have a probe tip that can be used intra-orally as well as on external skin, (E) will enable the user to control the intensity of heat stimuli and selectively activate nociceptive fiber types by controlling light power and pulse duration, and (F) register the reaction response in rodents.

描述（由申请人提供）：本I期SBIR的目标是设计、开发、测试和验证一种啮齿动物行为热刺激器，该热刺激器可以区分评估面部和口腔内的伤害感受器。目前还没有工具能够在动物或人类中进行面部或口腔内的热伤害感测绘。例如，投影仪灯泡发出的普通白光辐射热刺激会为可靠的测试提供过于明亮的视觉提示。众所周知的哈格里夫斯足底刺激装置不是纤维类型的选择，在三叉神经区域使用是不切实际的。进一步了解面部伤害感受器的位置和特性对于探索口腔-面部疼痛和神经病变的临床前模型以及针对三叉神经系统的镇痛操作具有重要意义。红外激光二极管刺激器的发展可能会导致一种临床研究工具，对检测口腔-面部疼痛疾病患者的感觉异常以及药物验证和发现具有重要意义。研究人员计划在第一阶段测试动物的口腔-面部区域。在第二阶段，研究人员计划继续测试正常人类志愿者和患者的口腔-面部区域，并制定口腔-面部定位自然疼痛的诊断标准。研究人员将设计、制造和测试一种面向面部的红外激光二极管热刺激器，该热刺激器(A)将提供准直光，在皮肤中产生热量，(B)避免对人类和动物的眼睛产生刺激，(C)允许定位和距离的灵活性，(D)探头尖端可用于口腔内和外部皮肤。(E)通过控制光功率和脉冲持续时间，使使用者能够控制热刺激的强度和选择性地激活伤害性纤维类型；(F)记录啮齿动物的反应反应。

项目成果

Ablation of rat TRPV1-expressing Adelta/C-fibers with resiniferatoxin: analysis of withdrawal behaviors, recovery of function and molecular correlates.

• DOI: 10.1186/1744-8069-6-94
• 发表时间: 2010-12-17
• 期刊: Molecular pain
• 影响因子: 3.3
• 作者: Mitchell K;Bates BD;Keller JM;Lopez M;Scholl L;Navarro J;Madian N;Haspel G;Nemenov MI;Iadarola MJ
• 通讯作者: Iadarola MJ