TIMED BREEDING CORE

定时育种核心

• 批准号: 7958573
• 负责人: Hans Michael Kubisch
• 金额: $ 6.04万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958573
• 关键词: Acquired Immunodeficiency Syndrome; Breeding; Computer Retrieval of Information on Scientific Projects Database; Conceptions; Dose; Female; Funding; Grant; Hour; Human; Infant; Injection of therapeutic agent; Institution; Intramuscular Injections; Live Birth; Methods; Pregnancy; Primates; Procedures; Progesterone; Research; Research Personnel; Resources; Seasons; Source; Time; Ultrasonography; United States National Institutes of Health; gene therapy; male; ovulation time; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: The timed-breeding program at the Tulane National Primate Research Center uses exogenous progesterone administration to control the time of ovulation. Methods: Human progesterone is administered by intramuscular injection at a dose of 5mg. The female is placed with the male 14 days after the last injection. Ultrasonography conducted 24 or 31 days after placing the female with the male confirms that pregnancy generally occurs 4 days after introduction to the male. This procedure allows for the efficient use of the males and provides a conception date+24 hours. Results/Discussion: In the spring/summer of 2008, 24 live births occurred as a result of time breeding efforts. These infants were assigned to either R. Veazey (AIDS research) or D. Phinney (gene therapy). For the 2008 breeding season, 15 females and 5 males are being used to provide infants to support a project of D. Phinney. Currently there are 2 confirmed pregnancies. The other females are awaiting ultrasounds and/or being placed with a male for breeding.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 背景资料：杜兰国家灵长类动物研究中心的定时繁殖计划使用外源性黄体酮来控制排卵时间。 方法：人孕酮5 mg肌肉注射。 最后一次注射后14天，将雌性动物与雄性动物放在一起。 在将雌性与雄性放置在一起后24或31天进行的超声波检查证实，怀孕通常发生在引入雄性后4天。 该程序允许有效利用雄性，并提供受孕日期+24小时。 结果/讨论：在2008年春季/夏季，由于时间育种的努力，发生了24例活产。 这些婴儿被分配到R。Veazey（艾滋病研究）或D. Phinney（基因疗法）。 在2008年的繁殖季节，15只雌性和5只雄性被用来提供婴儿，以支持D。菲尼 目前有2例确诊妊娠。 其他雌性正在等待超声波和/或与雄性一起进行繁殖。