Toxicity Of Lead In Children--Clinical Trial

铅对儿童的毒性--临床试验

• 批准号: 7327659
• 负责人: WALTER ROGAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7327659
• 关键词: Toxicity; Lead; Children; Clinical; Trial

In a randomized clinical trial of succimer, an oral chelating agent that lowers blood lead concentration, children with blood leads of 20 to 44 micrograms per deciliter were given succimer or placebo when they were about 2 years old and followed with cognitive and behavioral testing. We reported previously that, despite lower blood lead levels during treatment, children given succimer had test scores that were no different from those of children given placebo at ages five or seven years. This year we used the trial data set to determine whether the effects of blood lead on behavior were direct or were mediated through the effect on IQ. We found that lead has direct effects on externalizing behavior (pushing, shouting) but not on internalizing behavior (fears, worries). We have arranged with CDC to analyze blood samples collected in this project for mercury, which will allow a randomized trial of succimer for mercury chelation without enrolling any new subjects or collecting any specimens. We also used trial data to see if chelation therapy lowered blood pressure, which it did not.

在一项关于琥珀酸（一种降低血铅浓度的口服螯合剂）的随机临床试验中，血铅浓度为 20 至 44 微克/分升的儿童在大约 2 岁时服用琥珀酸或安慰剂，并随后进行认知和行为测试。我们之前报道过，尽管治疗期间血铅水平较低，但接受琥珀酸治疗的儿童的测试成绩与五岁或七岁时接受安慰剂的儿童没有什么不同。今年，我们使用试验数据集来确定血铅对行为的影响是直接的还是通过对智商的影响来介导的。我们发现铅对外化行为（推挤、喊叫）有直接影响，但对内化行为（恐惧、担忧）没有影响。 我们已与疾病预防控制中心安排分析该项目中收集的血液样本中的汞，这将允许对琥珀酸汞螯合进行随机试验，而无需招募任何新受试者或收集任何样本。我们还使用试验数据来观察螯合疗法是否可以降低血压，但事实并非如此。