Estrogenicity Of Soy Formula

大豆配方奶粉的雌激素作用

• 批准号: 7327670
• 负责人: WALTER ROGAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7327670
• 关键词: Estrogenicity; Soy; Formula

Genistein and daidzein are estrogenic isoflavones found in soybeans. Although they are about 1/10,000 as potent as estradiol, infants fed soy formula have serum concentrations that are up to 4 orders of magnitude higher than estradiol. Anatomic, sonographic, and other biochemical evidence of estrogen exposure has not been looked for in infants fed soy. Whether such widely used products do or do not have clinically detectable estrogenic activity in infants, the group with the highest exposure per kilo, is important clinically; in addition, it may be a crucial test of the ability of laboratory measures of estrogenicity to predict actual endocrine response in humans. We have done the field work for pilot studies to examine the natural history of estrogen responsive physiology in the newborn, and will use the results to develop a longitudinal study of the possible estrogenic effects of soy formula on infants. At the Boston Children?s Hospital, our collaborators in pediatric ultrasound have developed and assessed inter- and intra- rater reliability for examinations of the breast, uterus, ovaries, testes, prostate, adrenals, and thyroid. Using a protocol and eligibility criteria developed at NIEHS, they examined 96 girls, ranging in age from less than 48 hours to one year, and 60 boys, ranging in age from less than 48 hours to 6 months. We find that the methods are reliable, and that uterine and ovarian volume changes over time but that the endometrial stripe does not. Breast tissue and accompanying fat is readily imaged. At the Children?s Hospital in Philadelphia, our collaborators did physical examinations of the breasts and genitalia of 84 children total of both sexes ages from less than 48 hours to 6 months. We find that breast tissue varies over time, and that fat is distinguishable from gland. We also find that vaginal wall cells appear to be estrogen responsive. In urine samples collected over the first year, isoflavone concentrations ar 3-5 orders of magnitude higher in children fed soy formula. Equol is not present. We have also collected samples at this site for analysis of a variety of hormones but are still developing methods. We are analyzing the physical examination, ultrasound, and isoflavone data now, and are beginning to plan the next study.

染料木素和大豆黄酮是大豆中的雌激素异黄酮。虽然它们的效力大约是雌二醇的万分之一，但喂养大豆配方奶粉的婴儿血清浓度比雌二醇高4个数量级。在食用大豆的婴儿中，尚未找到雌激素暴露的解剖、超声和其他生化证据。这种广泛使用的产品在婴儿（每公斤接触量最高的群体）中是否具有临床可检测的雌激素活性，在临床上很重要；此外，这可能是一个至关重要的测试，实验室测量雌激素的能力，以预测实际的内分泌反应的人。我们已经进行了初步的实地研究，以检查新生儿雌激素反应生理的自然史，并将利用这些结果对大豆配方奶粉对婴儿可能产生的雌激素效应进行纵向研究。