Toxicity Of Lead In Children--Clinical Trial

铅对儿童的毒性--临床试验

• 批准号: 8336538
• 负责人: WALTER ROGAN
• 金额: $ 27.3万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8336538
• 关键词: 2 year old; Behavior; Blood Pressure; Blood specimen; Brain; Cadmium; Centers for Disease Control and Prevention (U.S.); Chelating Agents; Child; Clinical Trials; Cognition; Cognitive; Data; Defect; Development; Enrollment; Fatty Acids; Fishes; Lead; Lead Poisoning; Measures; Mercury; Oral; Poisoning; Polyunsaturated Fatty Acids; Reporting; Sampling; Source; Specimen; Succimer; Testing; Toddler; Toxic effect; behavior test; chelation; design; prevent; randomized trial

We did a clinical trial of succimer to treat moderately lead poisoned children. We found no effect of succimer treatment on cognition or behavior, reported previously. Recently, we have arranged with CDC to analyze blood samples collected in this project for methyl mercury, inorganic mercury, and cadmium, which allowed a randomized trial of succimer for chelation of these compounds without enrolling any new subjects or collecting any specimens. Succimer does not appear to be an efficacious chelating agent for mercury or cadmium. Neither mercury nor cadmium, measured at age 2 years, is associated with cognitive or behavioral test scores, and cadmium is not associated with blood pressure. Mercury at 7 years is associated with a small increase in the child's IQ, probably because the source of the mercury is dietary fish, and fish contains polyunsaturated fatty acids that are used in brain development. We are investigating whether we can analyze the samples for fatty acids and disentangle these effects.

我们做了一个琥珀酰亚胺治疗中度铅中毒儿童的临床试验。 我们发现琥珀酰亚胺治疗对认知或行为没有影响，以前报道过。 最近，我们与CDC安排分析在该项目中收集的甲基汞，无机汞和镉的血液样本，这使得琥珀酰亚胺螯合这些化合物的随机试验无需招募任何新的受试者或收集任何标本。 琥珀酰亚胺似乎不是汞或镉的有效螯合剂。 在2岁时测量的汞和镉都与认知或行为测试分数无关，镉与血压无关。 7岁时的汞与儿童智商的小幅增加有关，可能是因为汞的来源是饮食中的鱼类，而鱼类含有用于大脑发育的多不饱和脂肪酸。 我们正在研究是否可以分析样本中的脂肪酸，并解开这些影响。