Toxicity Of Lead In Children--Clinical Trial

铅对儿童的毒性--临床试验

• 批准号: 7967991
• 负责人: WALTER ROGAN
• 金额: $ 22.59万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7967991
• 关键词: 2 year old; Age; Blood; Blood Pressure; Blood specimen; Cadmium; Centers for Disease Control and Prevention (U.S.); Chelating Agents; Child; Clinical Trials; Cognitive; Data; Defect; Enrollment; Lead; Lead Poisoning; Mercury; Oral; Placebos; Randomized Clinical Trials; Randomized Controlled Clinical Trials; Reporting; Specimen; Succimer; Testing; Toddler; Toxic effect; behavior test; blood Pb concentration; blood lead; chelation; design; prevent

In a randomized clinical trial of succimer, an oral chelating agent that lowers blood lead concentration, children with blood leads of 20 to 44 micrograms per deciliter were given succimer or placebo when they were about 2 years old and followed with cognitive and behavioral testing. We reported previously that, despite lower blood lead levels during treatment, children given succimer had test scores that were no different from those of children given placebo at ages five or seven years. We have arranged with CDC to analyze blood samples collected in this project for methyl mercury, inorganic mercury, and cadmium, which will allowed a randomized trial of succimer for chelation of these compounds without enrolling any new subjects or collecting any specimens. Succimer does not appear to be an efficacious chelating agent for mercury or cadmium. Neither mercury nor cadmium is associated with cognitive or behavioral test scores, and cadmium is not associated with blood pressure

在一项关于琥珀酸（一种降低血铅浓度的口服螯合剂）的随机临床试验中，血铅浓度为 20 至 44 微克/分升的儿童在大约 2 岁时服用琥珀酸或安慰剂，并随后进行认知和行为测试。我们之前报道过，尽管治疗期间血铅水平较低，但接受琥珀酸治疗的儿童的测试成绩与五岁或七岁时接受安慰剂的儿童没有什么不同。 我们已与疾病预防控制中心安排分析该项目中收集的血液样本中的甲基汞、无机汞和镉，这将允许对琥珀酸螯合这些化合物进行随机试验，而无需招募任何新受试者或收集任何样本。 琥珀酰似乎不是汞或镉的有效螯合剂。 汞和镉均与认知或行为测试分数无关，镉与血压无关