Human Exposure To Halogenated Aromatic Compounds

人类接触卤化芳香族化合物

• 批准号: 8553690
• 负责人: WALTER ROGAN
• 金额: $ 11.68万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8553690
• 关键词: Aromatic Compounds; Censuses; Cessation of life; Chemicals; Child; Data; Evaluation; Excess Mortality; Exposure to; Growth; Growth and Development function; Health; Human; Liver diseases; Lupus; Malignant Neoplasms; Measures; Non-Malignant; North Carolina; Oils; Pattern; Persons; Poisoning; Polychlorinated Biphenyls; Puberty; Public Health; Registries; Reporting; Taiwan; Techniques; Time; Update; boys; cohort; cooking; exposed human population; girls; health organization; malignant stomach neoplasm; mortality

Using data from the Taiwanese death registry and the census of victims of the poisoning, we compared mortality at 28 years after the PCB exposure occurred. For the first time, there was excess mortality from cancer, specifically stomach cancer. This adds consistency to the evaluations made by several public health organizations that these chemicals are carcinogenic for humans. There was also an unexpected excess of deaths from systemic lupus, which has not been seen in other cohorts exposed to similar chemicals. Using the North Carolina data, we found that, by applying longitudinal techniques to analysis of our growth data, that girls who would go on the have early puberty were heavier than other girls by the time they were 6-12 months old. Boys had the same pattern, but it was less pronounced.

利用台湾死亡登记和中毒受害者普查的数据，我们比较了多氯联苯暴露发生后28年的死亡率。癌症，特别是胃癌的死亡率第一次出现了上升。这增加了几个公共卫生组织所作的评估的一致性，即这些化学品对人类具有致癌性。系统性狼疮的死亡率也出乎意料地高，这在其他接触类似化学物质的人群中是没有发现的。