Estrogenicity Of Soy Formula

染料木素和大豆苷元是在大豆中发现的雌激素异黄酮类化合物。尽管它们的效力比雌二醇小得多，但喂食大豆配方奶粉的婴儿的血清浓度比雌二醇高出4个数量级。在喂食大豆的婴儿中，还没有找到雌激素暴露的解剖学、超声和其他生化证据。无论这种广泛使用的产品在婴儿中是否具有临床可检测到的雌激素活性，每公斤接触量最高的一组，在临床上是重要的；此外，这可能是对实验室雌激素活性测量预测人类实际内分泌反应能力的关键测试。我们已经进行了实地研究，以检验新生儿雌激素反应生理学的自然历史，并利用这些结果对大豆配方奶粉对婴儿可能产生的雌激素效应进行了纵向研究。这项研究于2010年8月在费城儿童医院开始登记。 利用该项目的样本，我们与疾病控制中心合作，表明在缺碘婴儿中，较高的高氯酸盐暴露与较高的促甲状腺激素水平有关，但与较低的T4无关。这一发现需要进一步研究，我们将在新的纵向研究中进行。

Genistein and daidzein are estrogenic isoflavones found in soybeans. Although they are much less potent than estradiol, infants fed soy formula have serum concentrations that are up to 4 orders of magnitude higher than estradiol. Anatomic, sonographic, and other biochemical evidence of estrogen exposure has not been looked for in infants fed soy. Whether such widely used products do or do not have clinically detectable estrogenic activity in infants, the group with the highest exposure per kilo, is important clinically; in addition, it may be a crucial test of the ability of laboratory measures of estrogenicity to predict actual endocrine response in humans. We have done the field work for pilot studies to examine the natural history of estrogen responsive physiology in the newborn, and have used the results to develop a longitudinal study of the possible estrogenic effects of soy formula on infants. Enrollment in this study began in August, 2010 at Children's Hospital of Philadelphia. Using samples from this project, we collaborated with the Centers for Disease Control to show that, in iodine deficient infants, higher perchlorate exposure is associated with higher thyroid stimulating hormone level but not lower T4. This finding needs further research, which we will do in our new longitudinal study.