Estrogenicity Of Soy Formula

大豆配方奶粉的雌激素作用

• 批准号: 8149002
• 负责人: WALTER ROGAN
• 金额: $ 35.63万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8149002
• 关键词: soy

Genistein and daidzein are estrogenic isoflavones found in soybeans. Although they are much less potent than estradiol, infants fed soy formula have serum concentrations that are up to 4 orders of magnitude higher than estradiol. Anatomic, sonographic, and other biochemical evidence of estrogen exposure has not been looked for in infants fed soy. Whether such widely used products do or do not have clinically detectable estrogenic activity in infants, the group with the highest exposure per kilo, is important clinically; in addition, it may be a crucial test of the ability of laboratory measures of estrogenicity to predict actual endocrine response in humans. We have done the field work for pilot studies to examine the natural history of estrogen responsive physiology in the newborn, and have used the results to develop a longitudinal study of the possible estrogenic effects of soy formula on infants. Enrollment in this study began in August, 2010 at Children's Hospital of Philadelphia. Using samples from this project, we collaborated with the Centers for Disease Control to show that, in iodine deficient infants, higher perchlorate exposure is associated with higher thyroid stimulating hormone level but not lower T4. This finding needs further research, which we will do in our new longitudinal study.

金雀异黄酮和大豆黄酮是大豆中发现的雌激素异黄酮。尽管它们的效力远低于雌二醇，但喂养大豆配方奶粉的婴儿的血清浓度比雌二醇高出 4 个数量级。尚未在食用大豆的婴儿中寻找雌激素暴露的解剖学、超声检查和其他生化证据。这些广泛使用的产品是否对婴儿（每公斤暴露量最高的群体）具有临床可检测的雌激素活性，在临床上很重要；此外，这可能是对雌激素性实验室测量预测人类实际内分泌反应能力的重要测试。我们已经完成了试点研究的实地工作，以检查新生儿雌激素反应生理学的自然历史，并利用这些结果开展了一项关于大豆配方奶粉对婴儿可能的雌激素影响的纵向研究。 这项研究于 2010 年 8 月在费城儿童医院开始招募。 我们与疾病控制中心合作，利用该项目的样本证明，在缺碘婴儿中，较高的高氯酸盐暴露与较高的促甲状腺激素水平相关，但与较低的 T4 水平无关。 这一发现需要进一步研究，我们将在新的纵向研究中进行。