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Estrogenicity Of Soy Formula

Estrogenicity Of Soy Formula
大豆配方奶粉的雌激素作用
批准号:
8929714
负责人:
WALTER ROGAN
金额:
$21.31万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
染料木素和大豆苷元是在大豆中发现的雌激素异黄酮类化合物。尽管它们的效力比雌二醇小得多,但喂食大豆配方奶粉的婴儿的血清浓度比雌二醇高出4个数量级。我们一直在实地对9个月大的婴儿进行纵向研究,详细观察他们雌激素反应组织的生长和发育,以及性激素和促性腺激素。我们于2014年5月完成跟踪,并已开始数据分析。此外,我们今年报告了一种细胞学方法的验证,该方法可用于婴儿雌激素暴露。
英文摘要
Genistein and daidzein are estrogenic isoflavones found in soybeans. Although they are much less potent than estradiol, infants fed soy formula have serum concentrations that are up to 4 orders of magnitude higher than estradiol. We have been in the field with a longitudinal study of infants up to 9 months old, looking in detail at the growth and development of their estrogen-responsive tissue as well as sex hormones and gonadotropins. We completed follow-up in May, 2014, and have begun data analysis. In addition, we reported this year the validation of a cytological method for asessing estrogen exposure in infants.
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