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Estrogenicity Of Soy Formula

Estrogenicity Of Soy Formula
大豆配方奶粉的雌激素作用
批准号:
8929714
负责人:
WALTER ROGAN
金额:
$21.31万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
染料木黄酮和大豆黄酮是在大豆中发现的雌激素。虽然它们的效力远低于雌二醇,但喂食大豆配方奶粉的婴儿的血清浓度比雌二醇高出4个数量级。我们已经在该领域进行了一项长达9个月的婴儿纵向研究,详细观察了他们的雌激素反应组织以及性激素和促性腺激素的生长和发育。我们于2014年5月完成随访,并已开始数据分析。此外,我们今年报告了一种评估婴儿雌激素暴露的细胞学方法的有效性。
英文摘要
Genistein and daidzein are estrogenic isoflavones found in soybeans. Although they are much less potent than estradiol, infants fed soy formula have serum concentrations that are up to 4 orders of magnitude higher than estradiol. We have been in the field with a longitudinal study of infants up to 9 months old, looking in detail at the growth and development of their estrogen-responsive tissue as well as sex hormones and gonadotropins. We completed follow-up in May, 2014, and have begun data analysis. In addition, we reported this year the validation of a cytological method for asessing estrogen exposure in infants.
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