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Estrogenicity Of Soy Formula

Estrogenicity Of Soy Formula
大豆配方奶粉的雌激素作用
批准号：
8929714
负责人：
WALTER ROGAN
金额：
$21.31万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8929714
关键词：
BreastData AnalysesEstradiolEstrogensGenisteinGonadal Steroid HormonesGonadotropinsGrowth and Development functionInfantIsoflavonesLongitudinal StudiesMethodsModelingOrganOvaryReportingSerumSoybeansTissuesUrethraUterusVaginaValidationdaidzeinfeedingfollow-upsoy

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中文摘要
翻译
染料木素和大豆黄酮是大豆中的雌激素异黄酮。虽然它们的效力远不如雌二醇，但食用大豆配方奶粉的婴儿的血清浓度比雌二醇高4个数量级。我们对9个月大的婴儿进行了纵向研究，详细观察了他们的雌激素反应组织、性激素和促性腺激素的生长发育情况。我们于2014年5月完成随访，并开始数据分析。此外，我们今年报道了一种评估婴儿雌激素暴露的细胞学方法的验证。
英文摘要
Genistein and daidzein are estrogenic isoflavones found in soybeans. Although they are much less potent than estradiol, infants fed soy formula have serum concentrations that are up to 4 orders of magnitude higher than estradiol. We have been in the field with a longitudinal study of infants up to 9 months old, looking in detail at the growth and development of their estrogen-responsive tissue as well as sex hormones and gonadotropins. We completed follow-up in May, 2014, and have begun data analysis. In addition, we reported this year the validation of a cytological method for asessing estrogen exposure in infants.
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