Estrogenicity Of Soy Formula

大豆配方奶粉的雌激素作用

• 批准号: 8929714
• 负责人: WALTER ROGAN
• 金额: $ 21.31万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8929714
• 关键词: Breast; Data Analyses; Estradiol; Estrogens; Genistein; Gonadal Steroid Hormones; Gonadotropins; Growth and Development function; Infant; Isoflavones; Longitudinal Studies; Methods; Modeling; Organ; Ovary; Reporting; Serum; Soybeans; Tissues; Urethra; Uterus; Vagina; Validation; daidzein; feeding; follow-up; soy

Genistein and daidzein are estrogenic isoflavones found in soybeans. Although they are much less potent than estradiol, infants fed soy formula have serum concentrations that are up to 4 orders of magnitude higher than estradiol. We have been in the field with a longitudinal study of infants up to 9 months old, looking in detail at the growth and development of their estrogen-responsive tissue as well as sex hormones and gonadotropins. We completed follow-up in May, 2014, and have begun data analysis. In addition, we reported this year the validation of a cytological method for asessing estrogen exposure in infants.

染料木素和大豆苷元是在大豆中发现的雌激素异黄酮类化合物。尽管它们的效力比雌二醇小得多，但喂食大豆配方奶粉的婴儿的血清浓度比雌二醇高出4个数量级。我们一直在实地对9个月大的婴儿进行纵向研究，详细观察他们雌激素反应组织的生长和发育，以及性激素和促性腺激素。我们于2014年5月完成跟踪，并已开始数据分析。此外，我们今年报告了一种细胞学方法的验证，该方法可用于婴儿雌激素暴露。