HUMAN EXPOSURE TO HALOGENATED AROMATIC COMPOUNDS

人类接触卤代芳香族化合物

• 批准号: 6106649
• 负责人: WALTER ROGAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6106649
• 关键词: American; Taiwan; adolescence (12-20); anemia; clinical research; dichlorodiphenyltrichloroethane; embryo /fetus toxicology; environmental contamination; environmental toxicology; epidemiology; female; goiter; halobiphenyl /halotriphenyl compound; human milk; human puberty; human subject; liver disorder; longitudinal human study; middle childhood (6-11); placental transfer; racial /ethnic difference; steroid hormone metabolism

SUMMARY OF WORK: PCBs, a family of industrial chemicals, and DDE, the most stable metabolite of the pesticide DDT, contaminate body fat and thus the fat in breast milk of human beings throughout the world. We have followed since birth a cohort of 900 children born between 1978 and 1982 in North Carolina, USA, to determine effects of prenatal and lactational exposure to PCBs and DDE. These children have no special chemical exposure. Samples of breast milk were collected throughout lactation and were analyzed for PCBs and DDE. We collected information on lactation duration, and thus we can estimate both transplacental exposure and exposure through milk. Starting in 1993, we sent annual questionnaires to the families asking the child's height, weight, and onset of menstruation (if female) and Tanner stage; we use a modification of the Tanner scale in which line drawings of secondary sexual characteristics appear as an ordered progression. Either the parents, the child, or both may send information. Children are followed until they reach the final Tanner stage, and, if female, have begun menstruation. In preliminary analyses, girls who had higher transplacental DDE exposure may mature earlier. Boys and possibly girls with higher DDE exposure have higher peripubertal body mass indices. In Taiwan in 1979, more than 2000 people were poisoned by heat-degraded PCBs. We have shown that, after 13 years of follow-up, the survivors have an increase in mortality from non-malignant liver disease; however, they do not yet show an excess of liver cancer, which is occurring in survivors of a similar poisoning in Japan in 1969. We continue to follow this cohort, including the children born to poisoned mothers. In North Carolina, about 2/3 of the children have reported their pubertal status to us. Preliminarily, girls with higher prenatal DDE exposure mature earlier, and boys with higher prenatal DDE exposure have larger body mass indices, but these findings have no adjustment for any potential confounders. In Taiwan, we are beginning design of a clinical and endocrinological study of peri-pubertal girls who were in utero when their mothers were poisoned by PCBs/PCDFs.

工作摘要：多氯联苯，一族 工业化学品和DDE，最稳定的代谢物 杀虫剂滴滴涕，污染身体脂肪，从而污染母乳中的脂肪 世界各地的人类。从那以后我们就一直在跟踪 出生在1978年至1982年之间的900名儿童 美国北卡罗来纳州，以确定产前和 哺乳期暴露于多氯联苯和滴滴涕。这些孩子没有 特殊化学物质暴露。采集了母乳样本 并对其进行多氯联苯和DDE分析。我们 收集有关哺乳期的信息，因此我们可以 估计经胎盘暴露和通过牛奶暴露。 从1993年开始，我们每年向这些家庭发出调查问卷 询问孩子的身高、体重和月经开始时间(如果 女性)和Tanner舞台；我们使用Tanner标尺的修改 其中第二性特征的线条画显示为 有序的进程。父母、孩子或两者都可以 发送信息。孩子们一直被跟踪，直到他们进入决赛 晒黑阶段，如果是女性，已经开始月经了。在……里面 初步分析，经胎盘DDE较高的女孩 风险敞口可能会更早成熟。男孩和女孩可能有更高的 DDE暴露有较高的青春期体重指数。在……里面 1979年，台湾有2000多人被毒死 热降解的多氯联苯。我们已经证明，经过13年的 随访后，幸存者的死亡率有所增加 非恶性肝病；然而，它们还没有表现出 过量的肝癌，这发生在类似的 1969年在日本投毒。我们继续跟踪这群人， 包括中毒母亲所生的孩子。在北卡罗来纳州， 大约三分之二的孩子向我们报告了他们的青春期状况。 初步来说，出生前接触DDE较高的女孩成熟 更早，产前接触DDE较高的男孩有更大的 体重指数，但这些发现没有调整任何 潜在的混杂因素。在台湾，我们正在开始设计一种 青春期女孩的临床和内分泌学研究 在他们的母亲被多氯联苯/多氯二苯并呋喃中毒的宫内。