Estrogenicity Of Soy Formula

大豆配方奶粉的雌激素作用

• 批准号: 8553695
• 负责人: WALTER ROGAN
• 金额: $ 53.41万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8553695
• 关键词: 2 year old; Behavior; Bone Density; Bone Growth; Breast; Breast Feeding; Cattle; Child; Estradiol; Estrogens; Evaluation; Genistein; Gonadal Steroid Hormones; Gonadotropins; Growth and Development function; Infant; Isoflavones; Language Development; Longitudinal Studies; Methods; Milk; Modeling; Organ; Ovary; Play; Serum; Soybeans; Tissues; Uterus; daidzein; feeding; soy

Genistein and daidzein are estrogenic isoflavones found in soybeans. Although they are much less potent than estradiol, infants fed soy formula have serum concentrations that are up to 4 orders of magnitude higher than estradiol. We have been in the field with a longitudinal study of infants up to 9 months old, looking in detail at the growth and development of their estrogen-responsive tissue as well as sex hormones and gonadotropins. We have developed methods for studying play behavior, bone density, and language acquisition in 1 and 2 year olds, and completed a pilot recruitment evaluation. For all these studies, the exposed group are children using soy formula, compared with breast fed or cow milk formula.

染料木黄酮和大豆黄酮是在大豆中发现的雌激素。虽然它们的效力远低于雌二醇，但喂食大豆配方奶粉的婴儿的血清浓度比雌二醇高出4个数量级。我们已经在该领域进行了一项长达9个月的婴儿纵向研究，详细观察了他们的雌激素反应组织以及性激素和促性腺激素的生长和发育。 我们已经开发了研究1岁和2奥尔兹游戏行为、骨密度和语言习得的方法，并完成了试点招募评估。 在所有这些研究中，接触组是使用大豆配方奶粉的儿童，而不是母乳喂养或牛奶配方奶粉。