HUMAN EXPOSURE TO HALOGENATED AROMATIC COMPOUNDS

人类接触卤代芳香族化合物

• 批准号: 6432294
• 负责人: WALTER ROGAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6432294
• 关键词: American; Taiwan; adolescence (12-20); anemia; clinical research; dichlorodiphenyltrichloroethane; embryo /fetus toxicology; environmental contamination; environmental toxicology; epidemiology; female; goiter; halobiphenyl /halotriphenyl compound; human milk; human puberty; human subject; liver disorder; longitudinal human study; middle childhood (6-11); placental transfer; racial /ethnic difference; steroid hormone metabolism

In the North Carolina follow up study of puberty, height of boys at puberty increased with transplacental exposure to DDE, as did weight adjusted for height. Lactational exposure to DDE had no apparent effects; neither did transplacental or lactational exposure to PCBs. There was no effect on the ages at which pubertal states in boys were attained. There was some tendency for girls with higher transplacental PCB or DDE exposure to mature earlier, but the differences were not significant. Girls with the highest transplacental PCB exposures were heavier for their heights than other girls by 5.4 kg, but differences were significant only if the analysis was restricted to white girls. In Taiwan in 1979, more than 2000 people were poisoned by heat-degraded PCBs. We have shown that, after 13 years of follow-up, the survivors have an increase in mortality from non-malignant liver disease; however, they do not yet show an excess of liver cancer, which is occurring in survivors of a similar poisoning in Japan in 1969. We continue to follow this cohort, including the children born to poisoned mothers. In Taiwan, we are beginning design of a clinical and endocrinological study of peri-pubertal girls who were in utero when their mothers were poisoned by PCBs/PCDFs

在北卡罗来纳州对青春期的随访研究中，青春期男孩的身高随着经胎盘暴露于DDE而增加，根据身高调整的体重也是如此。哺乳期接触DDE没有明显的影响，也没有经胎盘或哺乳期接触多氯联苯。对男孩达到青春期状态的年龄没有影响。经胎盘接触多氯联苯或DDE的女孩有早熟的趋势，但差异不显著。经胎盘接触多氯联苯最多的女孩身高比其他女孩重5.4公斤，但只有在分析仅限于白色女孩时，差异才有意义。1979年，台湾有2000多人因热降解的PCB而中毒。我们已经表明，经过13年的随访，幸存者的非恶性肝病死亡率增加;然而，他们还没有显示出过多的肝癌，这是发生在1969年日本类似中毒的幸存者。我们继续跟踪这一群体，包括中毒母亲所生的孩子。在台湾，我们开始设计一项临床和内分泌学研究，研究对象是母亲被多氯联苯/多氯二苯并呋喃中毒时还在子宫内的围青春期女孩