JDRF STUDY OF AUTOIMMUNITY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该建议涉及目前知识中的三个主要空白。首先，缺乏糖尿病特异性T细胞活性的可接受和可重复的测量;其次，除了HLA之外，难以鉴定糖尿病相关基因，（人白细胞抗原基因，其赋予1型糖尿病以及其他自身免疫性疾病的风险，其子集已经在其与1型糖尿病风险的关联方面得到充分描述）;第三，需要改善临床试验参与者的代谢结果测量。因此，我们将使用新的方法充分描述这些参数在糖尿病风险或糖尿病受试者中的特征。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposal addresses three major gaps in current knowledge. First, the absence of an accepted and reproducible measure of diabetes specific T cell activity; second, the difficulties in identifying diabetes-associated genes in addition to HLA, (Human Leukocyte Antigen genes, which confer risk for type 1 diabetes as well as other autoimmune diseases, subsets of which have been well described in terms of their association with risk of type 1 diabetes); third, the need to improve metabolic outcome measures for people enrolled in clinical trials. We will therefore fully characterize these parameters in subjects at risk for or with diabetes using novel methods.