JDRF STUDY OF AUTOIMMUNITY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposal addresses three major gaps in current knowledge. First, the absence of an accepted and reproducible measure of diabetes specific T cell activity; second, the difficulties in identifying diabetes-associated genes in addition to HLA, (Human Leukocyte Antigen genes, which confer risk for type 1 diabetes as well as other autoimmune diseases, subsets of which have been well described in terms of their association with risk of type 1 diabetes); third, the need to improve metabolic outcome measures for people enrolled in clinical trials. We will therefore fully characterize these parameters in subjects at risk for or with diabetes using novel methods.