SEARCH FOR DIABETES IN YOUTH OF THE PUGET SOUND

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。关于美国青少年糖尿病患病率和发病率的数据有限，各种糖尿病类型的比例尚不清楚。临床因素和胰岛素需求不再可靠地区分儿童糖尿病的类型。SEARCH for Diabetes in Youth是一个全国性的、多中心的、统一的方法，用于儿童和青少年糖尿病的病例确定、类型、监测和研究，该方法将根据糖尿病类型、年龄、性别和种族/民族来测量美国20岁以下青年人口中糖尿病的范围。次要目标包括制定确定糖尿病类型的实际方法，按类型描述儿童糖尿病及其并发症，并描述保健利用、护理过程和生活质量。全国六个中心的研究人员正在对600万具有广泛种族和社会经济代表性的青年（约占20个威斯康星大学人口的6%）进行监测，2001年确定了大约6000例流行糖尿病病例，2002-2004年每年确定了800例发病病例。华盛顿的研究对象是2001-2004年间居住在普吉特海湾的所有年龄在20岁以下的青少年糖尿病患者，其中包括大约1500例流行病例和600例发病病例。SEARCH通过有限的数据、调查、简短的体格检查（身高、体重、血压、腰臀测量和黑棘皮病的评估）、实验室研究（糖尿病自身抗体、禁食和刺激c肽、血红蛋白A1c、血糖、血脂、尿白蛋白、肌酐、DNA提取和血浆储存）和访谈调查(诊断日期和设定、临床表现、年龄和诊断时的体型；其他病史和处方药物使用情况；种族/民族和社会经济地位、家庭结构和生活质量)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Data on prevalence and incidence of diabetes in US youth is limited and proportions with various diabetes types are unknown. Clinical factors and insulin requirements no longer reliably differentiate types of childhood diabetes. SEARCH for Diabetes in Youth is a national, multi-center, uniform approach to case ascertainment, typology, surveillance and research on diabetes in children and adolescents that will measure the extend of diabetes in the US population of youth under the age of twenty by type of diabetes, age, gender and race / ethnicity. Secondary objectives include developing practical approaches to identifying diabetes type, describing childhood diabetes and its complications by type, and characterizing health care utilization, processes of care and quality of life. Researchers at six centers across the country are conducing surveillance on 6 million youth with wide ethnic and socioeconomic representation (~6% of the 20 UW population), identifying approximately 6000 prevalent diabetes cases in 2001, and 800 incident cases per year in 2002-2004. The Washington study population is all youth with diabetes in 2001-2004 who are under age 20 and reside in the Puget Sound, which includes approximately 1500 prevalent and 600 incident cases. SEARCH is collecting information through limited data, surveys, brief physical examinations (height, weight, blood pressure, waist to hip measurement and assessment for acanthosis nigricans), laboratory studies (diabetes autoantibodies, fasting and stimulated C-peptide, hemoglobin A1c, blood glucose, lipids, urine albumin, creatinine, DNA extraction, and plasma storage), and interview surveys (date and setting of diagnosis; clinical presentation, age and body size at diagnosis; other medical history and use of prescription medications; race / ethnicity and socioeconomic status, family structure, and quality of life).