JDRF STUDY OF AUTOIMMUNITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该提案解决了当前知识中的三个主要差距。第一，缺乏可接受和可重复的糖尿病特异性T细胞活性测量；第二，除人类白细胞抗原(人类白细胞抗原基因，与1型糖尿病和其他自身免疫性疾病的风险相关，其亚型已被很好地描述为与1型糖尿病风险的关联)之外，识别糖尿病相关基因的困难；第三，需要改善参与临床试验的人的代谢结果测量。因此，我们将使用新的方法对糖尿病高危人群或糖尿病患者的这些参数进行充分的表征。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposal addresses three major gaps in current knowledge. First, the absence of an accepted and reproducible measure of diabetes specific T cell activity; second, the difficulties in identifying diabetes-associated genes in addition to HLA, (Human Leukocyte Antigen genes, which confer risk for type 1 diabetes as well as other autoimmune diseases, subsets of which have been well described in terms of their association with risk of type 1 diabetes); third, the need to improve metabolic outcome measures for people enrolled in clinical trials. We will therefore fully characterize these parameters in subjects at risk for or with diabetes using novel methods.