SEARCH for Diabetes in Youth 3: Washington Site, Part B

项目摘要 青少年糖尿病研究是一项正在进行的多中心研究， 种族多样的青年糖尿病患者的研究。根据RFA-DP 10 -001， 组成部分B，SEARCH队列研究将利用这一独特资源，继续研究选定的 鼓励参与者解决以下目标：1）评估以下疾病的患病率、发生率和风险因素： 慢性微血管（视网膜病变、肾病和自主神经病变）的选定标志物， 糖尿病大血管并发症（高血压、动脉硬化）; 2）评估发病率和风险 糖尿病急性并发症的因素，包括严重低血糖和糖尿病酮症酸中毒; 3） 对死亡率进行监测; 4）确定护理障碍、护理质量和 过渡到成人护理影响糖尿病相关的健康结果，包括生活质量。覆盖在这些 目的，我们将重点关注种族/民族和其他社会文化因素的影响，以及生物化学方面 糖尿病类型，糖尿病相关的健康结果。该队列研究将进行一项面对面的 对2002年或之后发生的糖尿病事件的研究性访视，糖尿病持续时间> 5年， 完成基线数据（预期n=3699）。在本研究期间，病史、人体测量、 将收集和分析生化、生理和调查数据。华盛顿的网站 包括西雅图周边的5个普吉湾县（King、Kitsap、Pierce、Thurston和Snohomish）， 塔科马。我们已经成功注册了超过3，700名参与者，我们是第二大 在完成的调查和基线访问总数方面，对后续行动的回应率很高 访问，以及华盛顿研究人员在糖尿病及其并发症方面的重要专业知识，我们正在 能够很好地实现本研究的目标。这项研究将利用的规模和种族多样性， 研究人群，以确定传统的，临床的， 糖尿病类型;美国的主要种族/种族群体;以及采用一种新的方法来隔离 传统的临床糖尿病类型的病理生理尺寸。因此，这项队列研究具有很高的 对来自所有主要种族的青年糖尿病患者的临床护理产生重大影响的可能性 在美国和国家公共卫生政策。

Project Summary SEARCH for Diabetes in Youth (SEARCH) is an on-going, multi-center study containing the largest and most ethnically diverse population of youth with diabetes ever studied in the US. In response to RFA-DP10-001, Component B, the SEARCH Cohort Study will utilize this unique resource by continuing the study of selected SEARCH participants to address the following Aims: 1) assess the prevalence, incidence, and risk factors for selected markers of chronic microvascular (retinopathy, nephropathy, and autonomic neuropathy) and macrovascular complications (hypertension, arterial stiffness) of diabetes; 2) assess the incidence and risk factors for acute complications of diabetes including serious hypoglycemia and diabetic ketoacidosis ; 3) conduct surveillance of mortality; and 4) determine the degree to which barriers of care, quality of care, and transition to adult care impact diabetes-related health outcomes including quality of life. Overlaid across these Aims, we will focus on the impact of race/ethnicity and other sociocultural factors, and biochemical dimensions of diabetes type, on diabetes-related health outcomes. The SEARCH Cohort Study will conduct an in-person research study visit on SEARCH participants incident in 2002 or later, with duration of diabetes > 5 years and with baseline data completed (expected n=3699). During this study medical history, anthropometric, biochemical, physiologic, and survey data will be collected and analyzed. The Washington SEARCH site includes 5 Puget Sound counties (King, Kitsap, Pierce, Thurston, and Snohomish) surrounding Seattle and Tacoma. We have successfully registered over 3,700 participants, and we are the second largest SEARCH site in terms of total number of surveys and baseline visits completed. With a high response rate to follow-up visits, and the significant expertise of Washington investigators in diabetes and its complications, we are strongly positioned to meet the aims of this study. This study will exploit the size and ethnic diversity of the study population to identify differences in both processes of care and health outcomes by traditional, clinical diabetes type; by the major race/ethnic groups in the US; and by employing a novel approach to segregate traditional clinical diabetes types by pathophysiologic dimensions. Thus, the SEARCH cohort study has a high likelihood of making a significant impact on the clinical care of youth with diabetes from all the major ethnic groups in the US and on national public health policy.