SEARCH for Diabetes in Youth 3: Washington Site, Part B

项目摘要 寻找青年糖尿病(SEARCH)是一项正在进行的、多中心的研究，包含了最大和最多的 曾在美国学习过的不同种族的糖尿病青年群体。响应RFA-DP10-001， B部分，搜索队列研究将利用这一独特资源，继续研究选定的 寻找参与者以解决以下目标：1)评估以下疾病的患病率、发病率和危险因素 选定的慢性微血管标记物(视网膜病变、肾病和自主神经病变)和 糖尿病大血管并发症(高血压、动脉僵硬)；2)评估发病率和风险 糖尿病急性并发症的相关因素，包括严重低血糖和糖尿病酮症酸中毒； 进行死亡率监测；以及4)确定护理障碍、护理质量和 过渡到成人护理会影响糖尿病相关的健康结果，包括生活质量。覆盖在这些 目标，我们将侧重于种族/民族和其他社会文化因素以及生物化学方面的影响 糖尿病类型对糖尿病相关健康结果的影响。搜索队列研究将进行面对面的 对2002年或以后发生的糖尿病病程为5年及以上的搜索参与者进行的研究访问 已完成基线数据(预期n=3699)。在这项研究中，医学史，人体测量学， 将收集和分析生化、生理和测量数据。华盛顿搜索网站 包括西雅图周围的5个普吉特湾县(国王、基特萨普、皮尔斯、瑟斯顿和斯诺霍米什)和 塔科马。我们已经成功注册了超过3700名参与者，我们是第二大搜索引擎 在已完成的调查和基线访问总数方面。有很高的随访率 访问，以及华盛顿研究人员在糖尿病及其并发症方面的重要专业知识，我们是 能够很好地满足本研究的目标。这项研究将开发大小和种族多样性的 研究人群以确定传统的、临床的护理过程和健康结果的差异 糖尿病类型；由美国主要种族/民族决定；并采用新的方法进行隔离 传统临床糖尿病按病理生理维度分型。因此，搜索队列研究具有很高的 对所有主要民族的青少年糖尿病患者的临床护理产生重大影响的可能性 组织在美国和国家公共卫生政策方面的合作。

Project Summary SEARCH for Diabetes in Youth (SEARCH) is an on-going, multi-center study containing the largest and most ethnically diverse population of youth with diabetes ever studied in the US. In response to RFA-DP10-001, Component B, the SEARCH Cohort Study will utilize this unique resource by continuing the study of selected SEARCH participants to address the following Aims: 1) assess the prevalence, incidence, and risk factors for selected markers of chronic microvascular (retinopathy, nephropathy, and autonomic neuropathy) and macrovascular complications (hypertension, arterial stiffness) of diabetes; 2) assess the incidence and risk factors for acute complications of diabetes including serious hypoglycemia and diabetic ketoacidosis ; 3) conduct surveillance of mortality; and 4) determine the degree to which barriers of care, quality of care, and transition to adult care impact diabetes-related health outcomes including quality of life. Overlaid across these Aims, we will focus on the impact of race/ethnicity and other sociocultural factors, and biochemical dimensions of diabetes type, on diabetes-related health outcomes. The SEARCH Cohort Study will conduct an in-person research study visit on SEARCH participants incident in 2002 or later, with duration of diabetes > 5 years and with baseline data completed (expected n=3699). During this study medical history, anthropometric, biochemical, physiologic, and survey data will be collected and analyzed. The Washington SEARCH site includes 5 Puget Sound counties (King, Kitsap, Pierce, Thurston, and Snohomish) surrounding Seattle and Tacoma. We have successfully registered over 3,700 participants, and we are the second largest SEARCH site in terms of total number of surveys and baseline visits completed. With a high response rate to follow-up visits, and the significant expertise of Washington investigators in diabetes and its complications, we are strongly positioned to meet the aims of this study. This study will exploit the size and ethnic diversity of the study population to identify differences in both processes of care and health outcomes by traditional, clinical diabetes type; by the major race/ethnic groups in the US; and by employing a novel approach to segregate traditional clinical diabetes types by pathophysiologic dimensions. Thus, the SEARCH cohort study has a high likelihood of making a significant impact on the clinical care of youth with diabetes from all the major ethnic groups in the US and on national public health policy.