NATURAL HISTORY OF THE DEVELOPMNT OF TYPE 1 DIABETES (TRIALNET PROTOCOL #TN-01)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 TrialNet是一个由18个临床中心组成的网络，与美国、加拿大、芬兰、英国、意大利、德国、澳大利亚和新西兰的筛查中心合作。 该网络致力于1型糖尿病（T1 D）的研究，预防和早期治疗。 Trial Net由NIH，国家糖尿病与消化和肾脏疾病研究所，国家过敏和传染病研究所，国家儿童健康和人类发展研究所，国家研究资源中心，美国卫生与人类服务部，JDRF和ADA支持。TrialNet将开发分为两大类的临床试验：针对新诊断的T1 D患者的试验和针对有T1 D风险的患者的试验。 T1 D发展的TrialNet自然史研究是一项多中心研究，采用前瞻性队列设计。 这项研究的目的是获得有关T1 D发病机制和自然史的信息，并促进招募和评估可能有资格参加T1 D预防试验的个人。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. TrialNet is a network of 18 Clinical Centers working in cooperation with screening sites throughout the US, Canada, Finland, United Kingdom, Italy, Germany, Australia, and New Zealand. The network is dedicated to the study, prevention, and early treatment of Type 1 Diabetes (T1D). Trial Net is supported by the NIH, National Institute of Diabetes & Digestive & Kidney Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, National Center for Research Resources, US Department of Health & Human Services, JDRF, and ADA. TrialNet will develop clinical trials that fall into 2 broad categories: those for individuals with newly diagnosed T1D and those for individuals at risk for T1D. The TrialNet Natural History Study of the Development of T1D is a multi-centered study, using a prospective cohort design. The goals of the study are to both gain information about the pathogenesis and natural history of T1D and to facilitate the recruitment and assessment of individuals who might qualify for T1D prevention trials.