TYPE 1 DIABETES GENETICS CONSORTIUM

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这是一项多中心的、国际的、有组织的努力，旨在确定决定一个人患糖尿病风险的基因。从家族和双胞胎研究得知，1型糖尿病的遗传基础是复杂的，包括影响大小的基因。已证实，人类白细胞抗原抗II类和I类基因在决定糖尿病风险方面起着重要作用。然而，很明显，人类白细胞抗原只占1型糖尿病总遗传风险的50%左右。在过去的二十年里，已经发现了其他几个与糖尿病风险有关的基因和基因多态。然而，由于临床和遗传资源有限，很难完全评估个体基因效应和基因相互作用的大小。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a multi-center, international, organized effort designed to identify the genes that determine one's risk of developing diabetes. From family and twin studies, it is known that the genetic basis of type 1 diabetes is complex, including genes with large and small effect. It is established that HLA Anti class II and class I genes play a major role in determining diabetes risk. However, it is apparent that HLA accounts for only approximately 50% of the total genetic risk of type 1 diabetes. Over the past two decades, several other genes and gene polymorphisms have been identified that contribute to diabetes risk. However, it has been difficult to fully assess the magnitude of individual gene effects and gene interactions due to limited clinical and genetic resources.