TYPE 1 DIABETES GENETICS CONSORTIUM

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a multi-center, international, organized effort designed to identify the genes that determine one's risk of developing diabetes. From family and twin studies, it is known that the genetic basis of type 1 diabetes is complex, including genes with large and small effect. It is established that HLA Anti class II and class I genes play a major role in determining diabetes risk. However, it is apparent that HLA accounts for only approximately 50% of the total genetic risk of type 1 diabetes. Over the past two decades, several other genes and gene polymorphisms have been identified that contribute to diabetes risk. However, it has been difficult to fully assess the magnitude of individual gene effects and gene interactions due to limited clinical and genetic resources.