SEARCH FOR DIABETES IN YOUTH OF THE PUGET SOUND

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在青少年中搜索糖尿病是一种全国性的、多中心的、统一的方法，用于儿童和青少年糖尿病的病例确定、类型分析、监测和研究，它将根据糖尿病的类型、年龄、性别和种族/民族来衡量美国20岁以下青年人口中的糖尿病程度。次要目标包括开发实用的方法来确定糖尿病类型，按类型描述儿童糖尿病及其并发症，并描述卫生保健利用、护理过程和生活质量。Search正在通过有限的数据、调查、简短的体检(身高、体重、血压、腰围到臀部的测量和对黑棘皮病的评估)、实验室研究(糖尿病自身抗体、禁食和刺激的C-肽、血红蛋白A1c、血糖、血脂、尿白蛋白、肌酐、DNA提取和血浆储存)和面谈调查(诊断日期和背景；诊断时的临床表现、年龄和体型；其他病史和处方药的使用；种族/民族和社会经济状况、家庭结构和生活质量)收集信息。关于健康行为(饮食、活动、睡眠、吸烟和抑郁)的其他问题也被问到了10岁以上的年轻人。每年都会对事件病例进行跟踪，以确定糖尿病的演变并评估并发症的发生。Search将评估20岁以下或按类型的青年糖尿病的患病率和发病率，制定分类方案以确定青年糖尿病的特征，记录风险因素和护理过程，并建立长期跟踪的基础设施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SEARCH for Diabetes in Youth is a national, multi-center, uniform approach to case ascertainment, typology, surveillance, and research on diabetes in children and adolescents that will measure the extent of diabetes in the US population of youth under the age of twenty by type of diabetes, age, gender and race / ethnicity. Secondary objectives include developing practical approaches to identifying diabetes type, describing childhood diabetes and its complications by type, and characterizing health care utilization, processes of care and quality of life. SEARCH is collecting information through limited data, surveys, brief physical examinations (height, weight, blood pressure, waist to hip measurement and assessment for acanthosis nigricans), laboratory studies (diabetes autoantibodies, fasting and stimulated C-peptide, hemoglobin A1c, blood glucose, lipids, urine albumin, creatinine, DNA extraction, and plasma storage), and interview surveys (date and setting of diagnosis; clinical presentation, age and body size at diagnosis; other medical history and use of prescription medications; race / ethnicity and socioeconomic status, family structure, and quality of life). Additional questions about health behaviors (diet, activity, sleep and smoking and depression) are being asked of youth over age 10. Incident cases will be followed yearly in order to define the evolution of diabetes and assess the occurrence of complications. SEARCH will estimate the prevalence and incidence of diabetes in youth less than 20 years or by type, develop typology schemes to characterize diabetes in youth, document risk factors and processes of care, and establish an infrastructure for long-term follow-up.