SEARCH for Diabetes in Youth 3: Washington Site, Part B

搜索青少年糖尿病 3：华盛顿网站，B 部分

• 批准号: 8146888
• 负责人: Catherine Pihoker
• 金额: $ 64.98万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8146888
• 关键词: SEARCH; Diabetes; Youth; Washington; Site

DESCRIPTION (provided by applicant): SEARCH for Diabetes in Youth (SEARCH) is an on-going, multi-center study containing the largest and most ethnically diverse population of youth with diabetes ever studied in the US. In response to RFA-DP10-001, Component B, the SEARCH Cohort Study will utilize this unique resource by continuing the study of selected SEARCH participants to address the following Aims: 1) assess the prevalence, incidence, and risk factors for selected markers of chronic microvascular (retinopathy, nephropathy, and autonomic neuropathy) and macrovascular complications (hypertension, arterial stiffness) of diabetes; 2) assess the incidence and risk factors for acute complications of diabetes including serious hypoglycemia and diabetic ketoacidosis ; 3) conduct surveillance of mortality; and 4) determine the degree to which barriers of care, quality of care, and transition to adult care impact diabetes-related health outcomes including quality of life. Overlaid across these Aims, we will focus on the impact of race/ethnicity and other sociocultural factors, and biochemical dimensions of diabetes type, on diabetes-related health outcomes. The SEARCH Cohort Study will conduct an in-person research study visit on SEARCH participants incident in 2002 or later, with duration of diabetes > 5 years and with baseline data completed (expected n=3699). During this study medical history, anthropometric, biochemical, physiologic, and survey data will be collected and analyzed. The Washington SEARCH site includes 5 Puget Sound counties (King, Kitsap, Pierce, Thurston, and Snohomish) surrounding Seattle and Tacoma. We have successfully registered over 3,700 participants, and we are the second largest SEARCH site in terms of total number of surveys and baseline visits completed. With a high response rate to follow-up visits, and the significant expertise of Washington investigators in diabetes and its complications, we are strongly positioned to meet the aims of this study. This study will exploit the size and ethnic diversity of the study population to identify differences in both processes of care and health outcomes by traditional, clinical diabetes type; by the major race/ethnic groups in the US; and by employing a novel approach to segregate traditional clinical diabetes types by pathophysiologic dimensions. Thus, the SEARCH cohort study has a high likelihood of making a significant impact on the clinical care of youth with diabetes from all the major ethnic groups in the US and on national public health policy.

描述（由申请人提供）：青少年糖尿病研究 (SEARCH) 是一项正在进行的多中心研究，包含美国有史以来研究的规模最大、种族最多样化的青少年糖尿病人群。为了响应 RFA-DP10-001 的 B 部分，SEARCH 队列研究将利用这一独特的资源，继续对选定的 SEARCH 参与者进行研究，以实现以下目标：1) 评估慢性微血管（视网膜病变、肾病和自主神经病变）和大血管并发症（高血压、动脉硬化）的选定标志物的患病率、发病率和危险因素。 糖尿病; 2）评估糖尿病急性并发症（包括严重低血糖和糖尿病酮症酸中毒）的发生率和危险因素； 3) 进行死亡率监测； 4) 确定护理障碍、护理质量和向成人护理过渡对糖尿病相关健康结果（包括生活质量）的影响程度。在这些目标的基础上，我们将重点关注种族/民族和其他社会文化因素以及糖尿病类型的生化维度对糖尿病相关健康结果的影响。 SEARCH 队列研究将对 2002 年或之后发生的 SEARCH 参与者事件进行现场研究访问，其中糖尿病病程 > 5 年且基线数据已完成（预计 n=3699）。在这项研究中，将收集和分析病史、人体测量、生化、生理和调查数据。 Washington SEARCH 站点包括西雅图和塔科马周围的 5 个普吉特海湾县（金县、基萨普县、皮尔斯县、瑟斯顿县和斯诺霍米什县）。我们已成功注册了 3,700 多名参与者，就完成的调查和基线访问总数而言，我们是第二大 SEARCH 网站。凭借对随访的高响应率，以及华盛顿研究人员在糖尿病及其并发症方面的丰富专业知识，我们有能力实现这项研究的目标。这项研究将利用研究人群的规模和种族多样性来确定传统临床糖尿病类型的护理过程和健康结果的差异；美国主要种族/族裔群体；并采用一种新方法根据病理生理学维度来区分传统的临床糖尿病类型。因此，SEARCH 队列研究很可能对美国所有主要种族的青少年糖尿病患者的临床护理以及国家公共卫生政策产生重大影响。